Dr. Yuh-Pyng Sher's Lab
Yuh-Pyng Sher
https://webap.cmu.edu.tw/TchEportfolio/index_1/ypsher
Research Field
Medicine
Introduction
- Professor Yuh-Pyng Sher's research endeavors center on unraveling the mechanisms crucial for cancer metastasis in diverse cancer types, such as lung cancer, esophageal squamous cell carcinoma, and pancreatic cancer. Employing a multidisciplinary approach, Professor Sher's team integrates biochemical methods, clinical studies, and experimental mouse models to comprehensively address these challenges and develop promising cancer treatments with translational potential.
- A significant focus of Professor Sher's recent research has been on elucidating the mechanisms governing KRAS activity, particularly in the context of KRAS protein degradation. This cutting-edge research has culminated in a publication in Nature Cancer in 2024. Over the past decade, Professor Sher has successfully guided four students to attain their Ph.D. degrees. To date, three doctoral students and one master's student have conducted their research under Professor Sher's mentorship. Professor Sher's laboratory warmly welcomes students or research fellows who harbor a fervent passion for cancer research, offering an opportunity to contribute to and thrive in the dynamic research environment cultivated by the team.
- We foster a collaborative environment that nurtures independent, creative research and encourages critical thinking. We aim to establish an inspiring and inclusive research setting where individuals can thrive in their careers. Committed to innovation and translational research, we seek to make meaningful contributions to scientific knowledge and its practical applications.
- Our research efforts are generously supported by various organizations, including CMU&H, the National Science and Technology Council (NSTC), the Ministry of Education (MOE), the Ministry of Health and Welfare (MOHW), and the National Health Research Institute (NHRI). These collaborations and financial backing underscore our commitment to advancing research excellence and addressing key challenges in health and science.
Research Topics
- Targeting novel pathways to prevent cancer metastasis
- ADAM9 inhibitor development for cancer treatment
- Anti-cancer immunity
- Cancer vaccines
Honor
- 2022 Boehringer Ingelheim’s Grass Roots Program (Cancer Therapies)
- 2022 The 19th National Innovation Excelsior Award in the Academic Research Category
- 2020 The 17th National Innovation Award in the Academic Research Category
- 2016 Award of Travel Grant of the 75th Annual Meeting of the Japanese Cancer Association
- 2016 Invited speaker in Cancer Biology and Drug Discovery Ph.D. Program Retreat
- 2011 The first place in the poster competition in International Symposium on Translational Cancer Research in conjunction with the 15th Annual Meeting of the Taiwan Cooperative Oncology Group
- 2007 NHRI Postdoctoral Fellowship Award
- 2001 Travel Award of the Institute of Biomedical Sciences, Academia Sinica
- 1998 Travel Award of the Institute of Biomedical Sciences, Academia Sinica
- 1997 Excellent Thesis Prize in Medical College of National Taiwan University
Educational Background
- BS, Department of Medical Technology, College of Medicine, National Taiwan University, Taiwan (1994)
- MS, Department of Medical Technology, College of Medicine, National Taiwan University, Taiwan (1996)
- PhD, Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taiwan (2006)
- Postdoc in Center of Molecular Medicine, China Medical University Hospital, Taiwan (2007)
2 Vacancies
Job Description
This is an excellent opportunity for someone passionate about translational research and eager to gain hands-on experience in a dynamic research environment.
Preferred Intern Education Level
Applicants must have a master's degree in drug research and chemistry, life and biomedical sciences, pharmacology, or biology-related fields.
Skill sets or Qualities
1. We welcome motivated individuals with relevant backgrounds who are enthusiastic about engaging in biomedical or translational research.
2. Applicants should possess a passion for science and a strong inclination for problem-solving.
3. Proficiency in Microsoft Office and data analysis tools is essential for this role.
4. Preference will be given to candidates with prior laboratory experience in chemistry or biotechnology.