Biophysical?Mass Spectrometry?Laboratory
Research Field
Wen-Ping Peng received his Ph.D. degree (2004) from the Department of Physics at National Taiwan University. He is now a professor and head of Department of Physics at National Dong Hwa University.
My research interest is on the development of novel mass spectrometric methods for rapid identification of viruses, bacteria, cells, and on development of novel ion soft landing techniques using linear ion trap to mass-select high mass biomolecules and nanoparticles. An ambient ion focusing device is also developed to prepare ions in atmospheric conditions with the temperature control on droplets. We have studied ion transmission of high mass biomolecules and nanoparticles using multiple quadrupoles and linear ion trap mass spectrometer, cellular endocytocysis of nano-/micro-particles, algorithm and theory for rapid analysis of electrospray mass spectra of bioparticles, searching biomarkers of clinical bacteria, identification of microorganisms using mass spectrometry techniques, protein/antibody analysis using nanomaterials, MALDI sample preparation, polymer analysis, and development of plasma ionization techniques.
●Ion trap theory and instrumentation
●Pathogen identification using mass spectrometry techniques
●MALDI sample preparation and multiply charged ion formation mechanism
●Electrospray mass spectral interpretation
●Aerosol, viral and bacterial particle detection and mass analysis
●Nanodiamond materials for biomedical applications
●Megadalton MALDI linear ion trap mass spectrometer
●Ambient ion soft landing using electrospray ionization
- Young scholar award of Taiwan Society for Mass Spectrometry 2013.
- The paper, “Quantitaive measurement of nano-/microparticle endocytosis by cell mass spectrometry” was selected to be highlighted in the frontispiece at the beginning of the communication section by Angewandte Chemie International Edition (2010).
- International Journal of Mass Spectrometry Best Student Paper Award-Instrumentation (2004).
- The paper, "Laser-induced acoustic desorption mass spectrometry of single bioparticles", was recognized as a very important paper (VIP) by Angewandte Chemie International Edition (11-24-2005).
- Institute of Atomic and Molecular Sciences annual award for outstanding publication by a junior researcher (2005).
- The achievements of International Journal of Mass Spectrometry Best Student Paper Award (2004) and mass measurement of single bacteria particles were reported by Liberty Times in Taiwan.
- The paper published in the Journal of the American Chemical Society 126 (2004): 11766-11767 was recognized as very important paper of Academia Sinica in the year of 2005.
- The paper, "Optical detection methods for mass spectrometry of macroions", was elected as a top 5% paper of IAMS, Academia Sinica during the year of 2003 to 2005.
‧Avinash A. Patil, Zhe-Xuan Liu, Yi-Pang Chiu, Thị Khánh Ly Lại, Szu-Wei Chou, Chun-Yen Cheng, Wen-Min Su, Hong-Ting Liao, Justin Benedict A. Agcaoili, Wen-Ping Peng*, Development of a linear ion trap mass spectrometer capable of analyzing megadalton MALDI ions, Talanta, 259, 12455 (2023)
‧Shou-Yu Liang, Shih-Chih Wan, Yen-Peng Ho, Yu-Tze Horng, Po-Chi Soo*, Wen-Ping Peng*, Rapid Quantification of Polyhydroxybutyrate Polymer from Single Bacterial Cells with Mass Spectrometry, Analytical Chemistry, 94, 11734-11738 (2022)
‧ Avinash A. Patil, Mhikee Janella N. Descanzo, Justin Benedict A. Agcaoili, Cheng-Kang Chiang, Chia-Liang Cheng, Huan-Cheng Chang, Wen-Ping Peng*, Carboxylated/Oxidized Diamond Nanoparticles for Quantifying Immunoglobulin G Antibodies Using Mass Spectrometry, ACS Applied Nano Materials, 4, 8922-8936 (2021)
‧ Shao-Yu Liang, Avinash A. Patil, Chou-Hsun Han, Szu-Wei Chou, Wen Chang, Po-Chi Soo, Huan-Cheng Chang, Wen-Ping Peng*, Ionization of Submicrometer-Sized Particles by Laser-Induced Radiofrequency Plasma for Mass Spectrometric Analysis, Analytical Chemistry 90, 13236-13242 (2018)
‧ Avinash A. Patil, Cheng-Kang Chiang, Chen-Hao Wen, Wen-Ping Peng*, Forced dried droplet method for MALDI sample preparation, Analytica Chimica Acta, 1031, 128-133 (2018)
Ph.D., Department of Physics, National Taiwan University
2 Vacancies
Job Description
The scan function of LIT-MS operating in frequency scanning mode, periodic excitation, and inverse-q scan will be composed with Python program. The arbitrary waveforms will be executed and tested to perform the MS/MS functions as well as their mass resolutions. The broadband power amplifier, geometry of linear ion trap, laser irradiation and focusing spot will be tested. Besides, a quadrupole mass filter will be employed to study the conditions for fragmentations of macroions. The sample carriers and its motion will be programmed and tested.
Preferred Intern Education Level
master students and undergraduates are ok.
Skill sets or Qualities
1. Basic programming ability, e.g. Python and Labview.
2. electronics
3. Physics