Biomedical Materials Engineering
Research Field
Prof. Chi-Chang Lin received his PhD from Institute of Polymer Engineering, National Taiwan University of Science and Technology (NTUST) in 2003 and had experimenced including postdoctoral fellow in Liver Transplant Research Lab, in the Chang Gung Memorial Hospital-Kaohsiung Medical Centre (CGMH) (Aug. 2002–Jul. 2006); Aug. 2006–Jul. 2010: postdoctoral fellow Biosensor Lab in Institute of Biomedical Engineering, National Cheng Kung University (NCKU); Assistant Professor at Tunghai University (THU) (partial), Faculty of Chemical Engineering and Materials Engineering (ChE&MatE) (Aug. 2009–Jan. 2010); Research Professor in NCKU (Aug. 2010–Jan. 2012); Assistant Professor at ChE&MatE, THU (Feb. 2010- Jan. 2014); Associate Professor at ChE&MatE, THU (Feb. 2014–Jul. 2017); Professor at ChE&MatE, THU Engineering (Aug. 2017-now).
His research intresting major in biomedical Engineering related courses such as biotechnology, biomedical engineering, biopolymer, biochemistry, physiology etc. Design and preparation of hollow fiber based mini-dialyzer for hemodialysis application; surface modification of enzyme on hollow fibers for hemodialysis catalysis; designed a porcine hepatocytes entrapped hollow fibers based liver support system for acute and chronic liver failure pigs with noticeable prolonged survival time; design a novel microfluidic and nanofludic chips, nano-/micro-materials, and Raman spectroscopy for clinical bacteria isolation and in situ detection. Electro spinning and 3D printing of biopolymer modified with organic/inorganic moleculars for bone and skin tissue engineering.
He have got many important awards and contributes more than 40 times to international conference chairs/speakers and received more than 40 best paper awards (16 from nationa conference). He has contributed more than 70 articles to journals, 280 conference articles, and three books. He served as editor board member, peer reviewers (over 20 journals) and organizing committee of various academic journals, conferences and NSC council. 2016 International Invention Innovation Competition in Canada, iCAN 2016. Publications: over 70 publications, 3 chapters / book, 9 patents.
Research in BME Lab
Our research focus on biotechnology, biomedical engineering, biopolymer, biochemistry, physiology etc. Design and preparation of hollow fiber based mini-dialyzer for hemodialysis application; surface modification of enzyme on hollow fibers for hemodialysis catalysis; designed a porcine hepatocytes entrapped hollow fibers based liver support system for acute and chronic liver failure pigs with noticeable prolonged survival time; design a novel microfluidic and nanofludic chips, nano-/micro-materials, and Raman spectroscopy for clinical bacteria isolation and in situ detection. Electro spinning and 3D printing of biopolymer modified with organic/inorganic moleculars for bone and skin tissue engineering.
Research in BME Lab
Our research focus on Bio-artifical liver device, Biomaterials, Biosenser, Electrospinning nanofiber mat, Tissue engineering), Hemodialysis hollow fiber, Surface enhanced Raman spectroscopy for microorganism detection.
I. Hydrogels
A novel γ-PGA composite gellan membrane containing glycerol for guided bone regeneration, Materials Science and Engineering C 118(2021)111404.
Glycerol-modified γ-PGA and gellan composite hydrogel materials with tunable physicochemical and thermal properties for soft tissue engineering application, Polymer 230(2021)124049.
Dual RGD-immobilized Poly(L-lactic acid) by Atmospheric Pressure Plasma Jet for Bone Tissue Engineering, Colloids and Surfaces B: Biointerfaces 178 (2019) 358-364.
II. Mineralization of inorganic particle on bio-based membrane surface
Hydroxyapatite -mineralized on polyelectrolytes layer-by-layer-coated poly (lactic acid) nanofiber sheets for bone tissue engineering, Biomaterials Science BM-ART-09-2020-001671
Using calcium silicate to regulate the physicochemical and biological properties when using β-tricalcium phosphate as bone cement, Materials Science and Engineering C 43(2014)126-134.
Odontogenic differentiation of human dental pulp cells by calcium silicate materials stimulating via FGFR/ERK signaling pathway, Materials Science and Engineering C 43(2014)359-366.
III. Electrospinning
Production, Optimization and Characterization of Polylactic Acid Microparticles using Electrospray with Porous Structure, Applied Sciences-Nanotechnology and Applied Nanosciences section, 11(2021)5090
Preparation and characterization of electrospun polylactic acid/sodium alginate/orange oyster shell composite nanofiber for biomedical application. Journal of the Australian Ceramic Society 56 (2020) 533–543.
Novel Electrospun Polycaprolactone/Graphene Oxide/Fe3O4 Nanocomposites for Biomedical Applications. Colloids and Surfaces B: Biointerfaces 172 (2018)718-727.
A novel antibacterial nanofibers mat made of co-axial electrospun polycaprolactone/ silver nitrate/zinc oxide composites. Advanced Nano-Bio-Materials and Devices 2(2018) 275-286.
IV. Surface modification of nanofiber mat
Indocyanine green based fluorescent polymeric nanoprobes for in vitro imaging, Journal of Biomedical Materials Research: Part B - Applied Biomaterials 108(2020)538-554.
Dual RGD-immobilized Poly(L-lactic acid) by Atmospheric Pressure Plasma Jet for Bone Tissue Engineering, Colloids and Surfaces B: Biointerfaces 178 (2019)358-364.
Encapsulation of indocyanine green (ICG) in poly(lactic acid) (PLA) nanofibers for using as a nanoprobe in biomedical diagnostics, Materials letter 228(2018)148–1511.
Osteogenesis of human adipose-derived stem cells on poly(dopamine)-coated electrospun poly(lactic acid) fiber mats, Materials Science and Engineering C 58(2016)254-263.
Chitosan-coated electrospun PLA fibers for rapid mineralization of calcium phosphate. International Journal of Biological Macromolecules 68(2014)39-47.
V. Surface enhanced Raman spectroscopy
High efficiency SERS detection of clinical microorganism by low cost silver-mirror reacted filter membrane and pattern recognition techniques. Sensors and acuators B 241(2017)1–9.
AuNPs@mesoSiO2 composites for SERS detection of DTNB molecule. Biosensors and Bioelectronics 51(2014)297-303.
A filter-like AuNPs@mesoSiO2 SERS substrate for S. aureus detection. Biosensors and Bioelectronics 53(2014)519-527.
VI. Clinical infectious and microorganism detection
Tracking the Reflective Light Particles Spreading on the Cornea: An Emerging Assessment for Tear Film Homeostasis. Translational Vision Science & Technology 32(2019)1-9.
Differentiation between Infectious and Non-infectious Ulcerative Keratitis by Raman Spectra of Human Teardrops: A Pilot Study, Investigative Ophthalmology & Visual Science 53(2012)1436-44.
Tear Analytical Model Based on Raman Microspectroscopy for Investigation of Infectious Diseases of Ocular Surface, Investigative Ophthalmology & Visual Science 52(2011)4942-50.
A filter-like AuNPs@mesoSiO2 SERS substrate for S. aureus detection. Biosensors and Bioelectronics 53(2014)519-527.
Rapid Discrimination of Bacteria and Bacteriophages by Raman Spectroscopy, Applied Mechanics and Material 284-287(2013)523-527
Discrimination of Clinical Microorganism using Raman Spectroscopy and Pattern Recognition Techniques, World Congress on Engineering 2(2017) 1081-1084.
Prof. Chi-Chang Lin received many important awards and contributes more than 40 times to international conference chairs/speakers and received more than 40 best paper awards (16 from nationa conference). He has contributed more than 70 articles to journals, 280 conference articles, and three books. He served as editor board member, peer reviewers (over 20 journals) and organizing committee of various academic journals, conferences and NSC council. 2016 International Invention Innovation Competition in Canada, iCAN 2016. Publications: over 70 publications, 3 chapters / book, 9 patents.
Prof. Chi-Chang Lin received PhD from Institute of Polymer Engineering, National Taiwan University of Science and Technology (NTUST) in Jan. 2003; MS from Institute of Polymer Engineering, NTUST in 1998; BS from Department of Polymer Engineering, NTUST in 1994.