Name: Yi-Chao Lee

Academic Experience

2019-present Professor, Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University,  Taipei, Taiwan

2014-2019  Associate Professor, Ph.D. Program for Neural Regenerative Medcine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

2011-2014 Assistant Professor, Ph.D. Program for Neural Regenerative Medcine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

Administrative Experience

2023-present Director of Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University,  Taipei, Taiwan

2023-present Director of International Master Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University,  Taipei, Taiwan

Our lab is interested in finding treatments for a genetic hereditary disease called tuberous sclerosis complex (TSC). This disease causes patients to have manifestations in multiple organs, including the brain. Most of the patients develop epileptic seizures and may be comorbid with neuropsychiatric disorders such as learning deficits, autism spectrum disorder, anxiety and others. We used animal behavioral tests like novel object recognition, open field and 3-chambered social tests, which are frequently used to mimic learning and memory functions, anxiety and autistic behaviors in humans respectively, to assess the preclinical therapeutic potentials of certain compounds in TSC. To further probe into the mechanisms of epilepsies in TSC, our lab has established the video EEG monitoring system, and a noninvasive brain magnetic resonance imaging modalities to detect alterations in microstructures and functional connectivity. We further used histopathological immunostaining approaches to validate the pathological signatures associated with the disease. We are currently working on translating our lab results into clinical studies.