I am an Assistant Professor at Taipei Medical University. My research expertise lies in neuroscience, with a particular focus on neuromuscular disorders, stem cell biology, and 3D cell culture engineering. I am committed to uncovering the molecular and cellular mechanisms underlying diseases such as Amyotrophic Lateral Sclerosis (ALS), using stem cell-based models to investigate potential therapeutic strategies.

In my lab, we employ advanced experimental systems, including 3D co-culture platforms and transgenic mouse models, to study how cellular interactions and signaling pathways contribute to the degeneration of motor neurons, neuromuscular junctions, and skeletal muscle. I welcome passionate and driven students to join us in advancing the understanding of these complex diseases and transforming scientific discoveries into meaningful clinical applications.

This is a Neuromuscular Research Lab that focuses on investigating fundamental and translational questions related to neuromuscular diseases. We utilize advanced 3D cell culture platforms and transgenic mouse models to explore the development, degeneration, and regeneration of the neuromuscular system.

Our team has established a 3D bilayer co-culture system that reconstructs functional motor units by integrating mouse-derived motor neurons, Schwann cells, and myogenic progenitors. This platform is combined with techniques such as primary cell isolation, gene expression profiling, immunofluorescence staining, and 3D fluorescence image reconstruction to dissect the cellular and molecular mechanisms underlying neuromuscular function and pathology.

Ongoing research projects include:

• Human Motor Unit Model: Establishing a human motor unit system using iPSC-derived motor neurons, Schwann cells, and myogenic progenitors to model neuromuscular development and disease.
   
• Sarcopenia: Investigating the pathogenesis and potential therapeutic strategies for age-related muscle loss.
   
• Amyotrophic Lateral Sclerosis (ALS): Exploring disease mechanisms and evaluating stem cell-based therapeutic approaches for ALS.

We are dedicated to building innovative platforms that bridge basic science and clinical application, and we welcome collaborators and students who are passionate about advancing neuromuscular research.