National Cheng Kung University

Cellular Signaling and Molecular Imaging

Wen-Tai Chiu
https://bme.ncku.edu.tw/p/404-1101-247562.php?Lang=zh-tw

Research Field

Medicine

Introduction

Dr. Wen-Tai Chiu received the Bachelor’s, Master’s and Ph.D. degrees from National Cheng Kung University, Taiwan in 1997, 1999 and 2007, respectively.  He has been a postdoctoral fellow at the University of Texas MD Anderson Cancer Center from 2008 to 2010. Prof. Chiu is currently a full professor in the Department of Biomedical Engineering at National Cheng Kung University.  His research interests lie in the area of Ca2+ signaling and molecular imaging of cancers. Much of his work has been on improving the understanding, design, and performance of Ca2+ in focal adhesion dynamics, cell migration, metastasis and chemoresistance.

Welcome to the Labratory of Cellular Signaling and Molecular Imaging (CSMI) in the Department of Biomedical Engineering at National Cheng Kung University. Prof. Wen-Tai Chiu is the PI of CSMI Lab. Prof. Chiu has been engaged in Ca2+-related research for many years, including the regulation of Ca2+ on focal adhesion dynamics, carcinogenesis and chemoresistance. Our lab has also combined engineering technology to construct an optogenetic platform, which can accurately create different Ca2+ oscillations in time and space scales different from traditional chemical stimulation. In addition, we are proficient in various molecular optical imaging, which can reveal the dynamics and changes of various molecules and ions in living cells. National Cheng Kung University has the best Bioimaging Core Facility in Taiwan, which is affiliated with the National Core Facility for Biopharmaceuticals of the National Science and Technology Council. PI (Prof. Wen-Tai Chiu) is the leader of this core facility. Therefore, we are skilled in many advanced equipment and technology for molecular imaging.

 


Research Topics

Ion and molecular imaging, live-cell imaging, Ca2+ signal regulation, epithelial-to-mesenchymal transition, cell death analysis and ancer metastasis in small animals are major skills in the CSMI Lab.

Three major research topics are currently conducting in our lab:

  1. Effects of the Bcl-2 pore-forming domain on Ca2+ signaling and cell death.
  2. Effect of cooking oil fuel compoments on lung cancer carcinogenesis.
  3. Drug development for polycystic kidney disease.
  4. Hypoxia induced FYN activation in regulation of TNBC metastasis.
  5. The molecular mechanism of Ca2+ signaling in regulating autophagy formation.  
     

Honor

2023    Outstanding Teaching Award, National Cheng Kung University
2019    Outstanding Teaching Award, National Cheng Kung University
2017    Outstanding Teaching Award, National Cheng Kung University
2016    Award for Excellence in Tutoring, Department of Biomedical Engineering, National Cheng Kung University
2015    Outstanding Research Award, College of Engineering, National Cheng Kung University
2015    Raising Star of Young Faculty, College of Engineering, National Cheng Kung University


Educational Background

2002-2007    Ph.D., Institute of Basic Medical Sciences, National Cheng Kung University, Taiwan
1997-1999    M.S., Department of Physiology, National Cheng Kung University, Taiwan
1993-1997    B.S., Department of Life Sciences, National Cheng Kung University, Taiwan
 


2 Vacancies

Job Description

This internship is to offer two short-term internship opportunities for eligible students to cultivate their interests in the fields of bioimaging and signal transduction. Noted that students who are interested in pursuing their advanced careers or studies here with us will have the priority.

Preferred Intern Education Level

Junior or senior year of undergraduate, Master, PhD students are all avaliable.

Skill sets or Qualities

Basic knowledge of life sciences, cell biology and bioing.