Cellular Signaling and Molecular Imaging
Research Field
Dr. Wen-Tai Chiu received the Bachelor’s, Master’s and Ph.D. degrees from National Cheng Kung University, Taiwan in 1997, 1999 and 2007, respectively. He has been a postdoctoral fellow at the University of Texas MD Anderson Cancer Center from 2008 to 2010. Prof. Chiu is currently a full professor in the Department of Biomedical Engineering at National Cheng Kung University. His research interests lie in the area of Ca2+ signaling and molecular imaging of cancers. Much of his work has been on improving the understanding, design, and performance of Ca2+ in focal adhesion dynamics, cell migration, metastasis and chemoresistance.
Welcome to the Labratory of Cellular Signaling and Molecular Imaging (CSMI) in the Department of Biomedical Engineering at National Cheng Kung University. Prof. Wen-Tai Chiu is the PI of CSMI Lab. Prof. Chiu has been engaged in Ca2+-related research for many years, including the regulation of Ca2+ on focal adhesion dynamics, carcinogenesis and chemoresistance. Our lab has also combined engineering technology to construct an optogenetic platform, which can accurately create different Ca2+ oscillations in time and space scales different from traditional chemical stimulation. In addition, we are proficient in various molecular optical imaging, which can reveal the dynamics and changes of various molecules and ions in living cells. National Cheng Kung University has the best Bioimaging Core Facility in Taiwan, which is affiliated with the National Core Facility for Biopharmaceuticals of the National Science and Technology Council. PI (Prof. Wen-Tai Chiu) is the leader of this core facility. Therefore, we are skilled in many advanced equipment and technology for molecular imaging.
Ion and molecular imaging, live-cell imaging, Ca2+ signal regulation, epithelial-to-mesenchymal transition, cell death analysis and ancer metastasis in small animals are major skills in the CSMI Lab.
Three major research topics are currently conducting in our lab:
- Effects of the Bcl-2 pore-forming domain on Ca2+ signaling and cell death.
- Effect of cooking oil fuel compoments on lung cancer carcinogenesis.
- Drug development for polycystic kidney disease.
- Hypoxia induced FYN activation in regulation of TNBC metastasis.
- The molecular mechanism of Ca2+ signaling in regulating autophagy formation.
2023 Outstanding Teaching Award, National Cheng Kung University
2019 Outstanding Teaching Award, National Cheng Kung University
2017 Outstanding Teaching Award, National Cheng Kung University
2016 Award for Excellence in Tutoring, Department of Biomedical Engineering, National Cheng Kung University
2015 Outstanding Research Award, College of Engineering, National Cheng Kung University
2015 Raising Star of Young Faculty, College of Engineering, National Cheng Kung University
2002-2007 Ph.D., Institute of Basic Medical Sciences, National Cheng Kung University, Taiwan
1997-1999 M.S., Department of Physiology, National Cheng Kung University, Taiwan
1993-1997 B.S., Department of Life Sciences, National Cheng Kung University, Taiwan
2 Vacancies
Job Description
This internship is to offer two short-term internship opportunities for eligible students to cultivate their interests in the fields of bioimaging and signal transduction. Noted that students who are interested in pursuing their advanced careers or studies here with us will have the priority.
Preferred Intern Education Level
Junior or senior year of undergraduate, Master, PhD students are all avaliable.
Skill sets or Qualities
Basic knowledge of life sciences, cell biology and bioing.