Taipei Medical University

HuangFu Lab: Drug Discovery for Cancers and Beyond

Wei-Chun HuangFu
https://hub.tmu.edu.tw/en/persons/wei-chun-huang-fu

Research Field

Medicine

Introduction

Dr. Wei-Chun HuangFu received her BSc from National Tsing-Hua University, her MSc from Duke University, and her PhD from North Carolina State University. She completed her postdoctoral training at the University of Pennsylvania, USA. She is currently an Associate Professor at the Graduate Institute of Cancer Biology and Drug Discovery and the Vice Dean for International Affairs of the College of Medical Science and Technology (CoMST) at Taipei Medical University, Taiwan. She is dedicated to drug discovery, drug pharmacology, and efficacy evaluation, as well as investigating their mechanism of action.

Academic Experience

Associate Professor, Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University

Adjunct Associate Professor, Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University 

2013-2019 Assistant Professor, Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University

2007-2010 Postdoctoral Research Fellow, University of Pennsylvania, Philadelphia, PA, USA

Administrative Experience

2023- present Vice Dean for International Affairs, College of Medical Science and Technology, Taipei Medical University

2019-2020 Chief of International Research, Office of Global Engagement, Taipei Medical University

Drug Discovery for Cancers and Beyond 

We focus on developing novel small-molecule drugs for rare diseases and unmet clinical needs. We utilize an AI-assisted drug discovery platform to design and synthesize novel small molecules targeting specific disease targets including cancer and neurodegenerative diseases. This AI platform accelerates the drug discovery process, allowing us to quickly select drug candidates for development and provide help to those in need. My main responsibilities include drug pharmacology and efficacy evaluation and assisting in preclinical toxicology experiments.


Research Topics

Drug development for Cancer: We identify novel cancer targets and use an AI-assisted drug discovery platform to design and synthesize novel small molecules for these specific disease targets, especially for cancer types without effective treatment. Currently, we are examining the in vitro biological effect of novel DYRK1B inhibitors for pancreatic cancer treatment.

Drug development for Neurodegenerative disease: Alzheimer's disease is a neurodegenerative disorder characterized by a gradual and irreversible process of cognitive decline. It is prevalent among elderly adult patients. Unfortunately, there is no effective cure for AD except for a few drugs to alleviate the symptoms. We are investigating therapeutic methods for Alzheimer's disease and developing DYRK1A-specific inhibitors. We also use in vitro pharmacology to delineate these potential inhibitors' molecular mechanisms.


Honor

2023 Taipei Biotech Awards

2022 National Innovation Award 

2021 Selected for 1st batch UC Berkeley -Taiwan Health Innovation Accelerator 

2021 Future Tech Award 

2020 National Innovation Award 

2020 SmartLabs Innovation Challenge: Selected for the first training startup team

2019 NBRP Biomed Startup Challenge: Selected as one of the eight innovation teams by The International Biomedical Accelerator Training Program 

2019 Berkeley Skydeck Innovation Challenge: Selected by the University of Berkeley Skydeck Accelerator Training Program

2019 RESI Conference 2nd Winner Award


Educational Background

2002-2007 Ph.D., Molecular and Cellular Toxicology, North Carolina State University, USA

2000-2002 M.E.M, Ecotoxicology, Nicholas School of the Environment and Earth Sciences, Duke University, USA

1995-1998 B.S., Atomic Science, National Tsing-Hua University, Taiwan 


2 Vacancies

Job Description

Drug Design and Development Internship Training Program 

This program aims to offer students who have a keen interest in drug design and development an opportunity to delve into this field. Despite significant advancements in cancer therapies in recent years, there remain certain limitations, and cancer still stands as the leading cause of death globally. Therefore, it is crucial to craft precise therapeutic strategies to better target patients, and advance toward precision medicine.

During the internship, students will be afforded the chance to explore novel molecular targets, gain hands-on experience in molecular docking techniques, comprehend the details of tumorigenesis mechanisms, and explore potential therapeutic applications. Interns will also be tasked with conducting literature reviews and participating in experiments related to ongoing research projects.

Furthermore, students will receive comprehensive training in laboratory safety protocols and will be equipped with essential skills in experimental procedures, including molecular biology. Additionally, they will be provided with instruction in data analysis and enhancing their abilities in presenting research findings in a laboratory setting.

Preferred Intern Education Level

BSc / MSc / PhD in life and biomedical sciences, molecular biology, pharmacology, or biology-related fields. Medical students are also welcome.

Skill sets or Qualities

  • Molecular biology and biochemical knowledge and skills
  • Cell culture
  • Communicating skills in English (written and verbal)