Department of Applied Chemistry and Institute of Molecular Sciences
Research Field
Dr. Ian Liau is a professor of applied chemistry at National Yang-Ming Chiao-Tung University (NYCU) and holds a joint appointment with the Department of Biological Science and Technology. He earned his B.S. in Chemistry from the National Tsing Hua University (NTHU) in Taiwan and an M.S. in Chemistry from the National Taiwan University (NTU). He completed his Ph.D. in Physical Chemistry at the University of Chicago, USA. After earning his doctorate, Dr. Liau contributed to cutting-edge advancements in microfluidic technologies at Fluidigm Corporation in the United States. He later applied his expertise at the Biomedical Engineering Center of the Industrial Technology Research Institute (ITRI) in Taiwan, where he developed a renal function reader.
At NYCU, Dr. Liau leads the Biomedical Photonics Lab. His research spans biophysical and bioanalytical chemistry, primarily focusing on peptide–membrane interactions and translational medical research. His work has advanced our understanding of cardio-cerebrovascular diseases by leveraging state-of-the-art spectroscopy and microscopy techniques and innovative applications using zebrafish models. His studies on peptide–membrane interactions have shed light on critical mechanisms such as transmembrane transport and endosomal escape, which are pivotal in biologics and drug delivery systems.
Beyond his research, Dr. Liau is deeply committed to mentoring the next generation of scientists and fostering interdisciplinary collaboration. His laboratory offers a vibrant environment where interns can engage in pioneering research at the nexus of chemistry, biology, and medical science.
Welcome to the Liau Lab in the Department of Applied Chemistry at NYCU. Our lab is at the forefront of biophysical and bioanalytical chemistry, leveraging innovative optical spectroscopy and microscopy to tackle critical biological challenges. We are committed to integrating fundamental science with translational research to drive impactful advancements in both fundamental understanding and real-world applications.
Our lab fosters a dynamic and interdisciplinary research environment, offering opportunities for collaboration and discovery. We welcome researchers who are passionate about addressing complex biological questions with cutting-edge technologies and a drive for impactful scientific breakthroughs.
Our current research directions include:
- Fundamental Membrane Physical Chemistry: Delving into biological membranes' physical and chemical properties to elucidate the principles underlying their structure, dynamics, and interactions.
- Peptide-Membrane Interactions: Investigating the complex mechanisms of peptide–membrane interactions, including processes like endosomal escape essential for biologics and antimicrobial actions that inform therapeutic innovation.
- Translational Research in Cardio-Cerebrovascular Diseases: Utilizing cutting-edge optical technologies and nanomedicine to explore the mechanisms and progression of cardio-cerebrovascular diseases, bridging the gap between foundational science and clinical applications.
I am honored to have served in various roles within the Department of Natural Sciences and Sustainable Development, National Science and Technology Council (NSTC), Taiwan, contributing to advancing scientific research and collaboration. These positions include:
Coordinator, Nanoscience and Technology Program (2024/01 – Present)
Coordinator, International Collaboration Program (2022/01 – 2023/12)
Vice Coordinator, Nanoscience and Technology Program
Coordinator, Chemistry Program
Panelist, Chemistry Program
Ph.D. Physical Chemistry University of Chicago, Chicago, IL, U.S.A.
M.S. Physical Chemistry National Taiwan University, Taipei, Taiwan
B.S. Chemistry National Tsing Hua University, Hsinchu, Taiwan
2 Vacancies
Job Description
Interns will receive mentorship from graduate students to perform experiments and activities aligned with the research focus, including:
- Optics Prototyping – Design and build optical setups for single-molecule tracking.
- Coding and Data Analysis – Develop scripts for analyzing single-molecule trajectories.
- Lipid Vesicle and Supported Lipid Bilayer Preparation – Create model membranes to study peptide-membrane interactions and dynamics.
- Comprehensive Cell Culture Models – Develop in vitro atherosclerosis models using advanced co-culture techniques to evaluate nanomedicinal interventions and mechanisms of action.
Preferred Intern Education Level
Preference will be given to undergraduate students who will have completed their second year or higher by the summer and have prior laboratory experience.
Skill sets or Qualities
- Technical Skills: Basic knowledge of optics, coding, chemistry, or cell culture is highly desirable.
- Analytical Thinking: Strong problem-solving skills with the ability to interpret complex datasets.
- Attention to Detail: Precision in experimental procedures and data analysis.
- Teamwork and Communication: Collaborative mindset with clear communication skills for effective teamwork.
- Eagerness to Learn: Enthusiasm for acquiring new technical and analytical skills in an interdisciplinary environment.
- Ethical Conduct: Commitment to research integrity and ethical laboratory practices.