Integrated Mechano Biosystems Lab
Research Field
Dr. Ting-Yuan (TY) TU has been an Associate Professor at the Department of Biomedical Engineering at National Cheng Kung University (NCKU) since 2022. He obtained his B.S. degree in Energy and Air-conditioning and Refrigeration Engineering from the National Taipei University of Technology, Taiwan, in 2007, and an M.S. degree in Applied Mechanics from the National Taiwan University Taipei, Taiwan, in 2009, with a focus on thermal-fluid engineering and MEMS. Dr. TU received his Ph.D. in Mechanobiology from the National University of Singapore, Singapore, in 2015, after pursuing his graduate studies at the Singapore-MIT Alliance for Research and Technology Centre (SMART) in Singapore.
Before his academic appointment at NCKU, Dr. TU worked as an Application Scientist at Clearbridge Biomedics, where he developed downstream assays to analyze circulating tumor cells in peripheral blood samples. Since joining NCKU as an Assistant Professor in 2016, Dr. TU's research has centered on developing more realistic biomimetic tumor microenvironments for cancer drug discovery, utilizing in vitro tumor models and 3D tumor invasive co-culture microfluidic platforms. His current research interests continue to focus on cancer drug discovery using these methods.
IMBSLab was founded in August 2016 as an interdisciplinary research lab integrating engineering and biology. Our mission is to advance the understanding of disease mechanisms by developing in vitro cell and tissue culture models.
Our research directions include the construction of a tumor microenvironment to investigate the process of cancer metastasis and the development of drugs to inhibit it. We also study liver tissue to understand the metabolic function of drugs and explore how mechanical stimulation and cell-to-cell attachment can lead to ligament degradation and lesions.
At IMBSLab, we believe that our research requires a multidisciplinary approach, and we place a high degree of interest in microfluidics, extracellular matrix materials, rapid manufacturing technology, and image analysis, among other fields. We welcome students and researchers from diverse backgrounds who share our passion for integrating engineering and biology to join us.
The International Internship Pilot Program offers a unique opportunity for you to actively engage in a comprehensive three-month study led by the Integrated MechanoBio System Laboratory. It presents an excellent avenue for individuals seeking to delve into the fundamentals of cancer science for Precision Medicine and its applications within microfluidic models, coupled with the creation of innovative drug screening algorithms.
Throughout the program's duration, you will immerse yourself in various aspects, gaining proficiency in working with cell cultures within microfluidic devices, acquiring skills in device fabrication, and delving into foundational molecular analysis techniques. This immersive experience encompasses both wet and dry lab settings, ensuring a holistic grasp of the subject matter.
Central to the program's curriculum is developing proficiency in diverse areas, including algorithm design and implementation, which will be essential for the algorithmic exploration of drug screening methodologies. A particular focus will be placed on leveraging artificial intelligence principles to formulate screening algorithms tailored for three-dimensional (3D) tumor models. These algorithms will play a pivotal role in identifying potential synergistic interactions among drugs, holding significant promise for advancing cancer therapeutics.
Beyond the technical aspects, the program also promises an enriching cultural experience. Participants will be welcomed into a Taiwanese-style laboratory setting, fostering an environment that uniquely blends cultural diversity and vibrant academic and research pursuits. This fusion of cultures and ideas will undoubtedly contribute to a well-rounded and inspiring educational journey.
In summary, this program extends an invitation to partake in a cutting-edge study conducted by the Integrated MechanoBio System Laboratory and embark on a transformative learning expedition. By engaging with both the intricacies of microfluidics and the realm of cancer science, participants will emerge equipped with practical skills and innovative insights. Moreover, the cultural diversity and academic dynamism will undoubtedly shape a holistic and memorable experience for all involved.
Outstanding Young Scholars Paper Award, Taiwan Chemical Sensors Association, Taiwan 2021
Teaching Excellence Award, National Cheng Kung University, Taiwan 2021
Future Star Research Award, College of Engineering, National Cheng Kung University, Taiwan 2021
Excellence Performance Award in Teaching Practice Research Grant, Ministry of Education, Taiwan, 2021
MOST Young Scholar Fellowship Program, Ministry of Science and Technology, Taiwan, 2019
1st Prize Young Investigator Award, Global Conference on Biomedical Engineering (GCBME), Taoyuan, Taiwan, 2018
Ph.D. in Mechanobiology, National University of Singapore, Singapore, 2015
M.S. in Applied Mechanics, National Taiwan University, Taiwan, 2009
B.S. in Energy and AC&R, National Taipei University of Technology, Taiwan, 2007