National Taiwan University of Science and Technology

Biomedical and Biochemical Engineering Lab

Yuan-Pang Hsieh
https://ch.ntust.edu.tw/p/404-1021-113837.php?Lang=zh-tw

Introduction

Dr. Hsieh obtained a dual bachelor's degree in Chemistry and Chemical Engineering from National Chung Hsing University in 2009. Subsequently, he earned his master's degree in Chemical Engineering from the same institution in 2011. His academic journey culminated with the completion of his Ph.D. in Chemical Engineering at Virginia Tech in the United States in 2020. During his doctoral pursuit, his research efforts were dedicated to the advancement of microfluidic devices and their application in profiling epigenetic regulation within the contexts of cancer and human diseases.

Following the attainment of his doctorate, he embarked upon postdoctoral training at Stanford University School of Medicine, concentrating on the development of innovative single-cell technology and the investigation of drug resistance genes through the utilization of CRISPR-Cas9 screening technology.

Since February 2023, Dr. Hsieh has assumed the role of assistant professor within the Department of Chemical Engineering at National Taiwan University of Science and Technology. His current scholarly focus resides in the extraction of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) from whole blood specimens utilizing microfluidic systems. This pioneering technology holds the promise of substantially advancing precision medicine and personalized healthcare endeavors.

Our laboratory is dedicated to the investigation of epigenetic regulation, cancer development, and precision medicine through the utilization of microfluidic systems. Our primary objective pertains to the advancement of novel technologies, characterized by both low-input requirements and high-throughput capabilities, to facilitate the comprehensive study of epigenetic regulation.


Research Topics
  1. Studying histone modification in breast cancer
  2. Profiling genome-wide long noncoding RNA binding sites in thyroid cancer
  3. Extracting circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) from whole blood samples 

Honor

Honorary member of Phi Tau Phi Scholastic Honor Society, June 2011

Summa cum laude and Valedictorian, June 2011

Stanford University School of Medicine Dean’s Postdoctoral Fellowship Award, June 2022


Educational Background

Ph.D., Chemical Engineering, Virginia Tech, Blacksburg, VA, USA, May 2020 

Advisor: Dr. Chang Lu              

Dissertation: New microfluidic technologies for studying histone modification and long non-coding RNA bindings

M.S., Chemical Engineering, National Chung Hsing University, Taiwan, June 2011

Advisor: Dr. Sung-Chyr Lin       

Thesis: Effects of PEGylation on enzyme activity

B.S., Chemical Engineering and Chemistry (double majors), National Chung Hsing University, Taichung, Taiwan, June 2009 

Advisor: Dr. Sung-Chyr Lin      

Project: Lipase-catalyzed transesterification of soy oil and isopropyl alcohol for the production of biodiesel in a batch reactor