Kaohsiung Medical University

Solid-phase synthesis of peptides and dendrimers

Chai-Lin Kao
https://wp.kmu.edu.tw/clkao/

Research Field

Chemistry

Introduction

Prof. Chai-Lin Kao received his Ph.D. from the School of Pharmacy, National Taiwan University. He worked on the development of the solid-phase method for the preparation of peptides and dendrimers. Recently, he expends his research interest to the areas of anti-biofilms and stroke treatment. 

My research interest is to develop efficient solid-phase synthetic methods for peptides and dendrimers. We have developed a safety-catch resin to prepare cyclic peptides and other peptide derivatives. Meanwhile, we also applied the solid-phase method to prepare pure dendrimers. Based on the developed methods, various functional peptides and dendrimers were prepared efficiently with high purity. Accordingly, we recently stepped into the field of anti-biofilm, delivery vehicles across the blood-brain barrier, and agents for treating stroke. 


Research Topics

Solid-phase peptide synthesis: especially on cyclic peptide and branched peptide

solid-phase dendrimer synthesis

Development of the anti-biofilm agents and the treatment of stroke.

Development of delivery vehicle across the blood-brain barrier


Honor

2020 KMU Outstanding Industry-University Cooperation Award

2019 KMU outstanding research paper award

2018: Asia core program lectureship-HongKong

2018: Asia core program lectureship-Malaysia

2014-2017: Excellent young researcher grant, Ministry of Science and Technology, Taiwan

2016: Excellent Research award /KMU


Educational Background

Ph. D.: School of Pharmacy, National Taiwan University 

B. Sc.: Department of Chemistry, National Taiwan University


2 Vacancies

Job Description

Study the mechanism of peptide crossing the blood-brain barrier. Applicants with experience in fundamental biological study are preferred. 

Preferred Intern Education Level

Graduate students

Skill sets or Qualities

Organic synthetic experience or biological experience.