Wan-Wan LIn
Research Field
Prof. Wan-Wan Lin obtained her doctoral degree of Pharmacology in National Taiwan University. She is mentor with high enthusiasm and passionate on discovering the mystery field of biology. Prof. Wan-Wan Lin's recent research covered on discovering the functional role of CASK, a scaffold protein ubiquitously expressed in various human organs. Besides, she also involved in studying the cancer metastasis, CNS and also retinal cell disease. To date, total of 3 post-doctoral research fellow, 4 doctoral student and 4 master student were worked in different field under Prof. Lin's supervision. We highly welcomed students or research fellow that are have high passionate and eagerness on biology experiment to join our lab.
We have been working on inflammation-related signaling pathways, gene regulation, and cancer development for many years. Besides exploring the molecular action mechanisms of several anti-inflammatory drugs, we demonstrated ligand-dependent and -independent action mechanisms of NOD2 in regulating TLR4 signaling and responses in macrophages. Regarding statins, which are HMG-CoA reductase inhibitors and widely used as lipid-lowering agents, we identified several novel anti-inflammatory and cell protective actions of statins, and provided valuable information to support their potential therapeutic uses in inflammatory diseases. Decoy receptor 3 (DcR3), a soluble receptor belonging to TNFR, is a biomarker of cancer progression. In our lab, we found DcR3 can exert inflammatory actions to modulate cancer progression via decoy and non-decoy action manners. Cell death is an important issue to control cellular homeostasis and biological functions. Among several types of programmed cell death, we have demonstrated the signaling cascades involved in necroptosis, parthanatos and autophagic death. In this respect, novel functions of caspase-8 in keratinocyte differentiation and autophagy induction were reported. At present, we are focusing on exploring the functional role of CASK in thecancer metastasis, CNS and also retinal cell disease.
1] Death mechanisms of necroptosis, autophagic cell death, and parthanatos.
2] Functions and signaling cascades of pathogen recognition receptors TLRs and NLRs.
3] Cellular functions and action mechanisms of DcR3 in disease pathogenesis.
4] Inflammasome activation
5] Energy regulation in stress conditions
Excellent Research Award from the National Science Council, ROC. (1998, 2002)
Excellent Research Project Award from the National Science Council, ROC (2009)
1998 Excellent Research Award from The Pharmacological Society in Taiwan
Distinguish Professor in the National Taiwan University (2006-present)
Excellent Research Award from the Chinese Society of Immunology (2016)
2021 Merit MOST Research Fellow
1990| PhD. (Graduate Institute of Pharmacology, College of Medicine)
1984| MS (Graduate Institute of Pharmacology, College of Medicine)
198 |BS (Graduate Institute of Pharmacology, College of Medicine
2 Vacancies
Job Description
N/A
Preferred Intern Education Level
Undergraduate student in medical sciences
Skill sets or Qualities
Prior research experience in in vitro and in vivo experiments from the Bioengineering department at the University of California, Berkeley.
2 Vacancies
Job Description
N/A
Preferred Intern Education Level
Undergraduate student in medical sciences
Skill sets or Qualities
Prior research experience in in vitro and in vivo experiments from the Bioengineering department at The University of California, Los Angeles.