I received my bachelor's degree in Chemistry in 1994 and my master's degree in Biochemistry in 1996 from National Chiao-Tung University, Taiwan. Following two years of mandatory military service in the Taiwan Air Force and three years of teaching in a senior high school, I embarked on my doctoral journey as a Ph.D. student in the Department of Chemistry & Biochemistry at UC Santa Barbara (UCSB), USA, in 2002, under the supervision of Prof. Norbert O. Reich. During this time, I was fortunate to receive a three-year scholarship from the Ministry of Education, Taiwan, for overseas studies. After successfully earning my Ph.D. in Protein Crystallography in 2007, I transitioned to UC Los Angeles (UCLA), where I joined the laboratory of Prof. Robert T. Clubb for a one-year post-doctoral training at the Molecular Biology Institute. In August 2008, I returned to Taiwan and assumed the role of Assistant Professor in the Department of Chemistry at National Central University (NCU). Currently, I hold the position of a full Professor and serve as an Associate Vice President in the Office of International Affairs at NCU, a role I have held since February 2021.
The ultimate goal of our research is to create novel biocomposites by combining biomacromolecules with Metal-Organic Frameworks (MOFs). MOFs act as a porous matrix capable of encapsulating enzymes, oligonucleotides, bacteria, etc. These biocomposites are expected to exhibit high-performance biological capabilities, enabling them to respond effectively to harsh environments in current industrial applications or cancer treatments.The synthetic methods for biomacromolecules@MOFs biocomposites often employed in our laboratory are known as the “water-based and mechanochemical approach” or the “environmentally friendly system” technique. These unique polymerization routes, including the water-based and grinding techniques, allow for the adjustment of (a) morphology, (b) size, and (c) organization of the materials. The synthesized materials are analyzed using X-ray powder diffraction, nitrogen adsorption/desorption, thermogravimetric analysis (TGA), scanning electron microscopy (SEM) or transmission electron microscopy (TEM) imaging, and biological activity analysis.
Our research is focused on obtaining nanostructured Metal-organic Frameworks (MOFs) through environmentally friendly synthetic methods, such as water-based processes or mechanochemical approaches. Our primary goal is to create biocomposites, including enzymes@MOFs. Additionally, we are actively developing the field of "MOF chemical biology," which involves studying the behaviors and structural changes of biomolecules embedded in MOFs.
2023-2024 Distinguished Journal Award-Word’s Top 1%, NCU (中大拔尖論文貢獻獎)
2023 Outstanding Industry Cooperation Award, NCU (中大優良產學合作獎)
2018-2024 Outstanding Research Award- NCU (中大學術研究傑出)
2014-2024 Excellent Paper Award-College of Science, NCU (理學院論文傑出)
2022 Distinguished Alumni-YanPing High School, Taipei (延平高中傑出校友)
2022 Outstanding Teacher Award, NCU (傑出教師)
2021 Scopus World’s Top 2% Scientists, (2021全球前2%頂尖科學家)
2016 - 2018 2-year Grant for Excellent Young Scholar, MOST (科技部優輕計畫)
2011 Outstanding Teaching Award, NCU (教學傑出獎)
2001-2004 Government Fellowship for Studying Abroad(教育部公費留美-鑑識科學)
2007 Ph.D. in Chemistry/Biochemistry, University of California at Santa Barbara
(UCSB) 加州大學聖塔芭芭拉分校Advisor: Prof. Norbert O. Reich.
Thesis title: Mechanistic Studies of C5-DNA Methylation: functional and
structural analysis of the catalytic residues in M.HhaI
2002 Forensic Science Ph.D. Training Program, University of Alabama,
Birmingham (UAB) 阿拉巴馬大學伯明罕分校
Advisor: Prof. Ray Liu (鑑識科學-劉瑞厚教授)
1996 M.S. in Bio-Analytical Chemistry from the Institution of Biological
Science and Technology, National Chiao-Tung University, Taiwan.
Prof. Allen C. Chang(國立交通大學生物科技研究所(第一屆)-張正教授)
1994 B.S. in Chemistry from the Department of Applied Chemistry, National
Chiao-Tung University, Taiwan (國立交通大學應用化學系第一屆)