Protein Crystallography and Structrual Biology Lab
Research Field
I am a Scientist and PI at the Life Science Group, Scientific Research Division of NSRRC. I am also jointly appointed with the National Tsing Hua University, National Cheng Kung University, and National Yang-Ming Chiao Tong University. My research fields range from synchrotron X-ray protein crystallography to molecular biophysics, structural biology, and biochemistry.
The lab is equipped with state-of-the-art instruments and infrastructure for structural biology, biochemistry, and biophysics, with frequent access to synchrotron protein crystallography and cryo-EM facilities.
The major research interest aims to study the structure and functional relationship of various proteins and biological assemblies. Current topics: various viruses to elucidate the mechanisms of VLP assembly and viral infection; membrane proteins and metalloproteins to understand the respiration and electron-transfer chain; proteins/enzymes involved in cancer development and diseases; membrane proteins accounting for drug targets.
- NSC/MOST Outstanding Young Scholar Research Project (2012 ~ 2016)
- NSRRC Outstanding Paper Award (2012, 2013, 2014, 2015, 2016, 2017, 2018)
- Lam Research Award (2016)
- Award of Future Tech of MOST (2017, 2019)
- Research on press & media: Grouper virus GNNV (2015), Outer membrane protein of Typhoid (2015), human hepatoma-derived growth factor (2018), shrimp nodavirus (2019), virus study on space (2021), honeybee-infecting virus (2023)
- Ph.D., Department of Crystallography, University of Pittsburgh, U. S. A. (1994-1999)
- M.S., Institute of Life Sciences, National Tsing-Hua University, Taiwan (1989-1991)
- B.S., Physics Department, National Tsing-Hua University, Taiwan (1985-1989)
2 Vacancies
Job Description
Protein expression, purification, crystallization and X-ray diffraction analysis
Preferred Intern Education Level
- Master students
- Ph.D. students
Skill sets or Qualities
Molecular biology, Biochemistry, Structural Biology, protein expression and purification