Chung Yuan Christian University

R509 lab (Epidermal stem cell)

Chung-Der Hsiao
http://cdhsiao.weebly.com/

Research Field

Biology

Introduction

Chung-Der Hsiao is Professor of Chung Yuan Christian University for Department of Bioscience Technology. He completed the undergraduate and graduate education in National Taiwan University (majored in Fishery Science). For postdoctoral training, he joined Dr. Pung-Pung Hwang's group at ICOB, Academia Sinica, and worked on fish physiology and bioinformatics. By 2007, Chung-Der was recruited by Chung Yuan Christian University and established his own laboratory, where he used the cutting-edge methods to generate many zebrafish disease models like apoptosis, obesity, skin cancer and aging. From 2012, Chung-Der was invited by GeneTex International Corp, Zgenebio Biotech and Taikong Corp as research consultant to initiate several cooperation projects on developing zebrafish antibodies, TALEN/CRISPR genome editing tools, transgenic fish, next generation sequencing technologies as well as Zebrafish behavioral assessment tools. From 2019, Chung-Der was promoted as full professor of Chung Yuan Christian University; and from 2021, Chung-Der was promoted as director of Research Center for Aquatic Toxicology and Pharmacology. Recent studies in Chung-Der’s lab focus on using deep learning technology to study animal neuro behavior and cardiac physiology. Chung-Der (H-index 35) is author of over 200 high impact journal articles, including Nature, Nature Physics, Biomedicine & Pharmacotherapy, Environmental pollution, Ecotoxicology and Environmental Safety etc. Heis frequently invited to talk at international and local conferences across a diverse range of fields, and has also spoken to school, students and public audiences. His research has strong application potentials and several patents have been issued regarding to use zebrafish as a human disease models like aging, obesity and cancer. (https://www.researchgate.net/profile/Chung_Der_Hsiao)

In our lab (http://cdhsiao.weebly.com/), we have setup several simple and cost-effective devices and deep learning-based methods to measure cardiac rhythm, blood flow, swimming activity and behavior in zebrafish. We believe those settings will benefit zebrafish community in the fields of cardiovascular physiology, excise physiology and behavior studies. Can visit our lab website for details.

 


Research Topics

Zebrafish genetic mutant screening and gene functional manipulation, High efficient plasmid construction by using Gateway recombination, High efficient transgenesis in Zebrafish by using Tol2 transposon, Conditionally gene expression by using Heat shock and Cre/LoxP system, Fluorescent double in situ hybridization and immunostaining, Confocal laser scan microscope and cell imaging, High resolution histology by using resin section, Image-based cytometry analysis of cell cycle deregulation, Transcriptomic analysis of gene expression by microarray and deep sequencing, TALEN/CRISPR-mediated gene knock out technology, Large-scale screening of suitable antibodies for serving Zebrafish community, Development of new small animal models suitable for performing drug screening, Animal behavioral assessment and new deep learning-based software development. Image analysis and locomotion tracking for experimental animals.

 


Honor

Awards/Honours:
2001 Chien-Tien Hsu’s Award Presentation, The Chinese Society of Cell and Molecular Biology
2001/2002  Outstanding Students Conference Travel Grant, Foundation for the Advancement of Outstanding Scholarship
2004  Distinguished Postdoctoral Fellowship, Academia Sinica
2004  Research Travel Grant, Max-Planck-Institute of Molecular Genetics, Germany
2004  Outstanding Post-Doctor Researchers Conference Travel Grant, Foundation for the Advancement of Outstanding Scholarship
2006  Visiting Scientist Research Grant, IMCB, A-Star, Singapore
2009  Visiting Scientist Research Grant, Genome Research Center, Academia Sinica
2020-2024  Annual subsidies research rewards for colleges and universities
 


Educational Background

B.Sc. (1991-1995) Department of Zoology, National Taiwan University, Taiwan
M.Sc. (1995-1998) Institute of Fisheries Science, National Taiwan University, Taiwan
Ph.D. (1998-2002) Institute of Fisheries Science, National Taiwan University, Taiwan
Postdoc (2003-2004) Institute of Molecular Biology, Academia Sinica, Taiwan
Distinguished Postdoc (2004-2006) Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan
Visiting scientist (2006/3-2006/12) Institute of Molecular and Cellular Biology (IMCB), A-Star, Singapore
Visiting scientist (2009/7-2009/12) Genome Research Center, Academia Sinica, Taiwan
Assistant professor (2007/8-2013/7) Department of Bioscience Technology, Chung Yuan Christian University, Taiwan; 
Associate professor (2013/8-2019/7) Department of Bioscience Technology, Chung Yuan Christian University, Taiwan; 
Professor (2019/7-now) Department of Bioscience Technology, Chung Yuan Christian University, Taiwan
Department of Chemistry, Chung Yuan Christian University, Taiwan
Vice Director (2021/7-now), Center of Nanotechnology, Chung Yuan Christian University, Taiwan
Director (2021/7-now), Research Center for Aquatic Toxicology and Pharmacology, Chung Yuan Christian University, Taiwan

 


2 Vacancies

Job Description

  1. Zebrafish behavior assay
  2. animal cardiac rhythm activity mesurement
  3. Deep learning application in aquatic animals
  4. Taxonomy and biodiversity studies using AI technology

Preferred Intern Education Level

Undergraduate or graduate students will be fine

Skill sets or Qualities

  • Genome Sequencing
  • Functional Genomics
  • Zebrafish
  • TALENs
  • CRISPR/CAS
  • Transgenesis
  • Genome Editing
  • De Novo Assembly
  • Gene Knockout
  • Knockout Models
  • Gene Knock-in
  • Bioinformatics
  • Developmental Toxicology
  • Brain Development
  • Bebavior
  • New tool development
  • Ecotoxicity
  • Animal species ID by using AI technology