National Taiwan University

Laboratory of Developmental Signaling

Jeff Shyh-Jye Lee
https://homepage.ntu.edu.tw/~jefflee/index.html?lang=en&v=research

Research Field

Biology

Introduction

Jeff, Shyh-Jye Lee is a highly accomplished professor and researcher specializing in developmental, cell, and molecular biology. He is a prominent Professor in the Department of Life Science at National Taiwan University and serves as a Research Fellow at the Center for Biotechnology. With a strong academic background, including a Ph.D. in Zoology/Cell Biology from Iowa State University, Lee has made significant contributions. He has been involved in various academic and leadership roles, such as serving as the President of the Taiwanese Society of Developmental Biology and directing the Center for Developmental Biology and Regenerative Medicine. Lee's expertise and research interests encompass diverse areas, including interneuromast cell quiescence, mitochondrial genomics, stem cells, neural progenitor cells, and the regulation of gene plasticity. Throughout his career, he has organized and participated in numerous scientific conferences and received several awards for his contributions to the field. Lee's work and publications have made valuable contributions to our understanding of biological processes and have been influential in the scientific community.

Embryonic development is an intricate and captivating process characterized by the fusion of mature haploid gametes to form a diploid zygote. This zygote undergoes rapid cleavage stages, leading to the formation of a blastocoel and the emergence of three germ layers through gastrulation. These germ layers subsequently contribute to the development of various organs along the three embryonic axes, ultimately shaping a sexually mature adult organism. Precise regulation of gene expression in each cell's genome is crucial during these developmental sequences, ensuring proper spatial and temporal coordination to establish a functional organism. Even minor errors in this regulation can lead to developmental abnormalities or even loss of life.

 


Research Topics

Our research aims to explore the intricate signal transduction mechanisms that drive these remarkable processes, utilizing cutting-edge biological tools. We employ zebrafish as a model organism to investigate these mechanisms, which offers valuable insights into the signal transduction pathways involved in embryonic development. Additionally, we delve into the study of human disease genes by creating zebrafish mutations through innovative techniques like CRISPR and other approaches. By leveraging these resources, we seek to deepen our understanding of embryonic development and shed light on the molecular underpinnings of human diseases.


Honor
2000NSC Class A Research Award
2002College of Science Teaching Award, National Taiwan University
2002University Teaching Award, National Taiwan University
2010University Teaching Service Award for 10 Years, National Taiwan University
2016University Teaching Award, National Taiwan University

2020

 

University Teaching Service Award for 20 Years, National Taiwan University

 

2022Advisory Award for the Innovative Undergraduate Research (Tze-I Hsu), MOST

Educational Background

B.S. in Animal Husbandry

Chung-Hsing University, Taichung, Taiwan

M.S. in Animal Sciences/Reproductive Physiology

University of Missouri, Columbia, Missouri, USA

Ph.D. in Zoology/Cell Biology

Iowa State University, Ames, Iowa, USA