Dr. Kuo Pin Chuang is a distinguished scientist with an extensive background in immunology and virology, recognized for pioneering contributions to our understanding of virus-host immune interactions. With a Ph.D. in Immunology from [University Name] and postdoctoral training at companion animal research and Graduate Institute of Animal Vaccine Research Center of the National Pingtung University of Science and Technology, Dr. Kuo Pin Chuang has spent over 20 years exploring the intricate mechanisms through which viruses interact with and evade the host immune system. Their work has yielded significant insights into how viruses adapt to hostile immune environments and how immune cells detect and respond to viral pathogens.
Throughout their career, Dr. Kuo Pin Chuang has aimed to bridge fundamental immunology with applied virology, specifically focusing on immune evasion strategies of major pathogens, such as FPV, DCH, PRRSV, and PED. They have been instrumental in identifying key viral proteins that interfere with host immune signaling pathways, enabling viruses to persist and evade elimination. By investigating these viral mechanisms, Dr. Kuo Pin Chuang seeks to unveil new therapeutic targets to enhance immune responses and develop novel antiviral strategies. Their work has influenced the development of targeted therapies that either bolster host immunity or disrupt viral immune evasion tactics, making strides toward innovative antiviral treatments and vaccines.
A core focus of Dr. Kuo Pin Chuang 's lab is the interplay between innate and adaptive immune responses to viral infections. Recognizing the pivotal role of innate immunity as the first line of defense, the lab studies how viruses manipulate innate immune sensors, such as pattern recognition receptors (PRRs), which detect viral RNA and DNA. Dr. Kuo Pin Chuang and their team analyze how viral evasion tactics impact the activation of key immune pathways, including the interferon response, a major antiviral defense mechanism. Their research provides a detailed picture of viral adaptation and persistence strategies by mapping the molecular interactions between viral proteins and host immune factors. These findings are essential for informing vaccine design and for improving antiviral responses, particularly in immunocompromised individuals and in populations at risk.
In addition to innate immune interactions, Dr. Kuo Pin Chuang ’s research also explores adaptive immunity, investigating how viral infections influence T and B cell responses. A significant aspect of this work addresses how some viruses can impair immune memory formation, making re-infection more likely and complicating vaccine development. By investigating the host immune landscape and pinpointing viral factors that disrupt immune cell function, the lab has provided critical insights into the challenges faced by vaccines in inducing long-lasting protection.
Dr. Kuo Pin Chuang collaborates with multidisciplinary teams across the globe, combining bioinformatics, structural biology, and molecular genetics to analyze virus-host interactions in unprecedented detail. Their lab uses cutting-edge technologies, including CRISPR gene-editing tools and next-generation sequencing, to dissect viral mechanisms and host defenses at the genomic and molecular levels.
Dr. Kuo Pin Chuang ’s work has been published in leading scientific journals and has attracted significant funding from prestigious institutions, including some international Funding. They have also mentored a new generation of scientists, instilling in them a rigorous approach to research and a passion for unraveling the complexities of virus-host dynamics. Driven by the pursuit of innovative therapeutic solutions, Dr. Kuo Pin Chuang continues to expand the boundaries of immunology and virology, contributing to a safer, more resilient future in the face of viral diseases.
My research lab has been established to study the immunological function and assess its efficacy and protection rate against its causative agent. Some of our researches are as follows:
- Development of fast detection kits against viruses
- Development of treatment strategies against viral infections by interferon
- Cell modification for virus production
- Vaccine and adjutant development for the virus
Honor:
2024 The best student research award of NPUST
2023 The first place lecture of 5th National Animal Husbandry and Veterinary Science Conference, Vietman
2023 The best Undergraduate thesis
2022 The Innovation and Entrepreneurship Competition
2022 The Winner of FITI (From IP to IPO program)
2022 The winner of the support Grant of the U-Start competition.
2021The best research of Thesis
2020 The best research of Thesis
2019The Best Research of Thesis
2018 The Best Research of Thesis
Publications
1. Wang Q, Huang WR, Chih WY, Chuang KP, Chang CD, Wu Y, Huang Y, Liu HJ. 2019. Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis. Vet Microbiol 235: 151-63
2. Yi CC, Liu CH, Chuang KP, Chang YT, Hu SY. 2019. A potential probiotic Chromobacterium aquaticum with bacteriocin-like activity enhances the expression of indicator genes associated with nutrient metabolism, growth performance and innate immunity against pathogen infections in zebrafish (Danio rerio). Fish Shellfish Immunol 93: 124-34
3. Chen YY, Yang WC, Chang YK, Wang CY, Huang WR, Li JY, Chuang KP, Wu HY, Chang CD, Nielsen BL, Liu HJ. 2020. Construction of polycistronic baculovirus surface display vectors to express the PCV2 Cap(d41) protein and analysis of its immunogenicity in mice and swine. Vet Res 51: 112
4. Santos HM, Chen CC, Tsai CY, Hsish YC, Chung FC, Tyan YC, Tayo LL, Chuang KP. 2020. Influence of pigeon interferon alpha (PiIFN-alpha) on pigeon circovirus (PiCV) replication and cytokine expression in Columba livia. Vet Microbiol 242: 108591
5. Santos HM, Tsai CY, Catulin GEM, Trangia KCG, Tayo LL, Liu HJ, Chuang KP. 2020. Common bacterial, viral, and parasitic diseases in pigeons (Columba livia): A review of diagnostic and treatment strategies. Vet Microbiol 247: 108779
6. Santos HM, Tsai CY, Maquiling KRA, Tayo LL, Mariatulqabtiah AR, Lee CW, Chuang KP. 2020. Diagnosis and potential treatments for acute hepatopancreatic necrosis disease (AHPND): a review. Aquac Int 28: 169-85
7. Chang CC, Silva BBI, Huang HY, Tsai CY, Flores RJD, Tayo LL, Tyan YC, Tsai MA, Catulin GEM, Chuang KP, Yang JL. 2021. Development and Validation of KASP Assays for the Genotyping of Racing Performance-Associated Single Nucleotide Polymorphisms in Pigeons. Genes (Basel) 12
8. Ho TC, Chang CC, Chan HP, Huang YF, Chen YA, Chuang KP, Lee CH, Yuan CH, Deng YZ, Yang MH, Tyan YC. 2021. Pulmonary Findings of [(18)F]FDG PET/CT Images on Asymptomatic COVID-19 Patients. Pathogens 10
9. Ho TC, Chen YA, Chan HP, Chang CC, Chuang KP, Lee CH, Yuan CH, Tyan YC, Yang MH. 2021. The Effects of Heterologous Immunization with Prime-Boost COVID-19 Vaccination against SARS-CoV-2. Vaccines (Basel) 9
10. Ho TC, Wang YH, Chen YL, Tsai WC, Lee CH, Chuang KP, Chen YA, Yuan CH, Ho SY, Yang MH, Tyan YC. 2021. Chloroquine and Hydroxychloroquine: Efficacy in the Treatment of the COVID-19. Pathogens 10
11. Huang HY, Silva BBI, Tsai SP, Tsai CY, Tyan YC, Lin TC, Flores RJD, Chuang KP. 2021. Immunogenicity and Protective Activity of Pigeon Circovirus Recombinant Capsid Protein Virus-Like Particles (PiCV rCap-VLPs) in Pigeons (Columba livia) Experimentally Infected with PiCV. Vaccines (Basel) 9
12. Padzil F, Mariatulqabtiah AR, Tan WS, Ho KL, Isa NM, Lau HY, Abu J, Chuang KP. 2021. Loop-Mediated Isothermal Amplification (LAMP) as a Promising Point-of-Care Diagnostic Strategy in Avian Virus Research. Animals (Basel) 12
13. Tsai CY, Hu SY, Santos HM, Catulin GEM, Tayo LL, Chuang KP. 2021. Probiotic supplementation containing Bacillus velezensis enhances expression of immune regulatory genes against pigeon circovirus in pigeons (Columba livia). J Appl Microbiol 130: 1695-704
14. Yang MH, Chen YA, Tu SC, Chi PL, Chuang KP, Chang CC, Lee CH, Chen YL, Lee CH, Yuan CH, Tyan YC. 2021. Utilizing an Animal Model to Identify Brain Neurodegeneration-Related Biomarkers in Aging. Int J Mol Sci 22
15. Chang CC, Ho TC, Lien CY, Shen DH, Chuang KP, Chan HP, Yang MH, Tyan YC. 2022. The Effects of Prior Mammography Screening on the Performance of Breast Cancer Detection in Taiwan. Healthcare (Basel) 10
16. Ho TC, Chang CC, Chan HP, Chung TW, Shu CW, Chuang KP, Duh TH, Yang MH, Tyan YC. 2022. Hydrogels: Properties and Applications in Biomedicine. Molecules 27
17. Huang Y-F, Ho T-C, Chang C-C, Shen DH-Y, Chan H-P, Chuang K-P, Tyan Y-C, Yang M-H. 2022. A Rare Adverse Effect of the COVID-19 Vaccine on Autoimmune Encephalitis. Vaccines 10: 1114
18. Silva BBI, Urzo MLR, Encabo JR, Simbulan AM, Lunaria AJD, Sedano SA, Hsu K-C, Chen C-C, Tyan Y-C, Chuang K-P. 2022. Pigeon Circovirus over Three Decades of Research: Bibliometrics, Scoping Review, and Perspectives. Viruses 14: 1498
19. Ho TC, Shen DH, Chang CC, Chan HP, Chuang KP, Yuan CH, Chen CN, Yang MH, Tyan YC. 2023. Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination. Vaccines (Basel) 11
20. Minh H, Son NV, Duc HM, Lin CN, Tyan YC, Chuang KP. 2023. Genetic diversity and relatedness of feline parvovirus in Vietnam and its potential implications for canine-feline transmission. Arch Virol 169: 11
21. Silva BBI, Chen JY, Villanueva BHA, Lu ZY, Hsing HZ, Montecillo AD, Shofa M, Minh H, Chuang JP, Huang HY, Saito A, Chuang KP. 2023. Genetic Diversity of Domestic Cat Hepadnavirus in Southern Taiwan. Viruses 15
22. Yang MH, Ho TC, Chang CC, Su YS, Yuan CH, Chuang KP, Tyan YC. 2023. Utilizing Proteomic Approaches to Uncover the Neuroprotective Effects of ACE Inhibitors: Implications for Alzheimer's Disease Treatment. Molecules 28
23. Ho T-C, Chuang S-C, Hung K-C, Chang C-C, Chuang K-P, Yuan C-H, Yang M-H, Tyan Y-C. 2024. Exploring risk factors for Raynaud's phenomenon post COVID-19 vaccination. Vaccine 42: 126470
24. Tyan YC, Chuang SC, Ho TC, Chuang KP, Yang MH. 2024. SARS-CoV-2 Vaccine Safety and Autoimmune Response. Vaccines (Basel) 12
25. Villanueva BHA, Chen JY, Lin PJ, Minh H, Le VP, Tyan YC, Chuang JP, Chuang KP. 2024. Surveillance of Parrot Bornavirus in Taiwan Captive Psittaciformes. Viruses 16
26. Villanueva BHA, Huang H-Y, Tyan Y-C, Lin P-J, Li C-W, Minh H, Tayo LL, Chuang K-P. 2024. Immune mRNA Expression and Fecal Microbiome Composition Change Induced by Djulis (Chenopodium formosanum Koidz.) Supplementation in Aged Mice: A Pilot Study. Medicina 60: 1545
27. Zainol MFA, Safiyanu MB, Abd Aziz S, Omar AR, Chuang KP, Mariatulqabtiah AR. 2024. Campylobacteriosis and Control Strategies against Campylobacters in Poultry Farms. Journal of Microbiology and Biotechnology 34: 987
Ph.D.
2005 National Cheng Kung University, Tainan, Taiwan
Major:
Basic Medical Sciences
Master.
2002 National Cheng Kung University, Tainan, Taiwan
Major:
Microbiology and immunology
Bachelor
2000 Soochow University. Taipei, Taiwan
Major:
Microbiology
2 Vacancies
Job Description
Dr. Kuo Pin Chuang ’s work has been published in leading scientific journals and has attracted significant funding from prestigious institutions, including some international Funding. They have also mentored a new generation of scientists, instilling in them a rigorous approach to research and a passion for unraveling the complexities of virus-host dynamics. Driven by the pursuit of innovative therapeutic solutions, Dr. Kuo Pin Chuang continues to expand the boundaries of immunology and virology, contributing to a safer, more resilient future in the face of viral diseases.
Preferred Intern Education Level
We accepted undergraduate and graduated student
Skill sets or Qualities
- Basic concept of the biology is ok