Dr. Eugene C. Lin is an accomplished researcher and educator in the field of chemistry and biochemistry. Currently serving as an associate professor at the Department of Chemistry and Biochemistry, National Chung Cheng University, Eugene’s academic journey spans continents—from earning his Ph.D. in Chemistry and Biochemistry at the University of California, San Diego to his subsequent postdoctoral research at Vanderbilt University Medical Center. His expertise lies in bioimaging and spectroscopic techniques with a special focus on molecular imaging methods that bridge the gap between chemical analysis and clinical applications. With a passion for innovative teaching and mentorship, Eugene has developed engaging courses (including biophysical chemistry) and has guided numerous graduate and undergraduate students to success in both research and competitive forums.
The laboratory under Dr. Lin's leadership is dedicated to advancing the emerging field of radiometabolomics—a discipline that integrates metabolic spectroscopy, magnetic resonance imaging (MRI), and quantitative statistical analysis to unravel biological and clinical phenomena at the molecular level. The lab is at the forefront of developing novel imaging techniques, such as cholesterol‐weighted MRI and chemical exchange saturation transfer (CEST) methods, that capture subtle metabolic variations in tissues. By designing innovative in vitro platforms (including three‐dimensional cell spheroid systems) and refining extraction protocols for cells, spheroids, and tissues, the group not only pushes the boundaries of imaging science but also lays the groundwork for more precise disease classification and diagnosis.
Radiometabolomics & Molecular Imaging:
Investigating metabolic changes and biochemical interactions in cells and tissues by integrating metabolic spectra with advanced MRI techniques. This includes the development of imaging protocols that capture molecular-level details of diseases.
Chemical Exchange Saturation Transfer (CEST) Imaging:
Focusing on the rNOE(−1.6) signal—a subtle yet crucial contrast arising from interactions between cholesterol and phosphatidylcholines. The lab’s work explores the underlying mechanisms of this signal and its potential to reveal lipid metabolism in various disease models.
Translational and Clinical Applications:
Applying advanced imaging methods to animal models and human-derived platforms for diseases such as brain tumors and nonalcoholic fatty liver disease (NAFLD). Collaborative projects with clinical partners are central to validating these techniques and translating them into diagnostic tools.
3D Cell Culture and Spheroid Analysis:
Developing in vitro models that closely mimic physiological conditions to study cellular responses and metabolic dynamics, thereby enhancing the predictive power of imaging biomarkers.
2022 Taiwan Comprehensive University System Young Scholars Award for Innovative R&D
2023 National Chung Cheng University Young Scholar Award
B.S. in Applied Chemistry, National Chi Nan University, 2006
M.S. in Chemistry, National Chung Hsing University, 2008
Ph.D in Chemistry and Biochemistry, University of California, San Diego, 2015
Postdoc Fellow, Vanderbilt University Institute of Imaging Science, 2015-2018
2 Vacancies
Job Description
1. Protein simulation/drug screening
2. Nanoparticle preparation
Preferred Intern Education Level
Graduate and undergraduate students
Skill sets or Qualities
Exhibits an enthusiastic attitude towards learning and a strong sense of responsibility.