Connective Tissue and Stem Cell Research lab
Research Field
PROFESSIONAL SOCIETY: American Association for Cancer Research American Society for Cell Biology American Society for Biochemistry and Molecular Biology 台灣生物化學及分子生物學學會 台灣基因體暨遺傳學會 台灣細胞醫療協會 中華民國基礎神經科學學會 台灣幹細胞學會
The focus of Connective tissue stem research lab are mainly investigate the role of MMP-7 in regulating stem cell and cancer stem cells differentiations through proteolytic processing several ECM, surface receptors, ligands and nucleus matrix proteins. Several plate forms were applied to study these important questions : Transgentic animals, Confocal microscopic analysis, soft X-ray tomography, spatial multiomic analysis. recently, our lab also focus on how mitochondria regulate nucleus epigentic controle by metbolic rewiring. The mitochondria transplant plateform were established to cooperate with clinical drctors to treat cardiac diseases, neuron degenerative diseases and cancer.
- Matrix Metalloprotease and their inhibitors
- ECM and Nucleus matrix remodeling by MMP peoteolytic processing and regulating stem cell differemtiations
- Role of MMP-7 in Cancer stem cell transformation and chemo-resistance
- Mitochondria transplantation, metabolic rewiring and epigenetic regulation
- Transgenic animal models: zebrafish and rodent
- intracellular vesicle transport and EV(exosome) scretion
Invited lecture and poster presentations by Gordon Research Conferences:
2024 Proteolytic enzymes and their inhibitors
2024 protein processing trafficking and secretion
6月 9 - 14, 2024 • Renaissance Tuscany Il Ciocco • Gordon Research ConferenceStatus: RegisteredRole: Speaker
2017 Matrix metalloproteases
7月 8 - 9, 2017 • University of New England • Gordon Research SeminarStatus: Acceptance CancelledRole: Attendee
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2 Vacancies
Job Description
Investigate mitochondria target therapy for the MPTP induced Parkinson's symdrome rodent model by using xenograft mouse model test mitochondria target molecules followed by Cell culture, confocal image analysis, western blot, PCR, biochemical analysis, etc.
Preferred Intern Education Level
under graduate students with strong motivation toward master/PhD graduate programe
MS students with strong motivation toward PhD program
Skill sets or Qualities
basic molecular cloning, western blot, rodent xenograft model, PCR, Rt-PCR, cell culture, frozen sections
2 Vacancies
Job Description
Investigate neuron protection target compounds screen for kainic acid induced hippocampal neuron primary cell culture model by using kainic acid induced seizure for primary hippocampal neuron Cell culture for target compounds screening followed by using confocal image analysis, western blot, PCR, biochemical analysis, transgenic animal model, etc.
Preferred Intern Education Level
undergraduate students with strong motivation towards MS/PhD program
MS students with strong motivation towards PhD program
Skill sets or Qualities
molecular cloning, PCR, RT-PCR, western blot, immuno-histochemistry, rodent model tech., frozen sectioning, IP. etc.