National Taiwan University, College of Medicine

Connective Tissue and Stem Cell Research lab

Wei-hsuan Yu, PhD
https://www.mc.ntu.edu.tw/ibmb/Vcard.action?q_type=A01&q_itemCode=735

Research Field

Medicine
Introduction

PROFESSIONAL SOCIETY:

American Association for Cancer Research

American Society for Cell Biology

American Society for Biochemistry and Molecular Biology

台灣生物化學及分子生物學學會

台灣基因體暨遺傳學會

台灣細胞醫療協會

中華民國基礎神經科學學會

台灣幹細胞學會

The focus of Connective tissue stem research lab are mainly investigate the role of MMP-7 in regulating stem cell  and cancer stem cells differentiations through proteolytic processing several ECM, surface receptors, ligands and nucleus matrix proteins. Several plate forms were applied to study these important questions : Transgentic animals, Confocal microscopic analysis, soft X-ray tomography,  spatial multiomic analysis. recently, our lab also focus on how mitochondria regulate nucleus epigentic controle by metbolic rewiring. The mitochondria transplant plateform were established to cooperate with clinical drctors to treat cardiac diseases, neuron degenerative diseases and cancer.

Research Topics
  1. Matrix Metalloprotease and their inhibitors
  2. ECM and Nucleus matrix remodeling by MMP peoteolytic processing and regulating stem cell differemtiations
  3. Role of MMP-7 in Cancer stem cell transformation and chemo-resistance
  4. Mitochondria transplantation, metabolic rewiring and epigenetic regulation
  5. Transgenic animal models: zebrafish and rodent

 

Honor

Invited lecture by Gordon Research Conferences:

2024 Proteolytic enzymes and their inhibitors

6月 9 - 14, 2024 • Renaissance Tuscany Il Ciocco • Gordon Research ConferenceStatus: RegisteredRole: Speaker

2017 Matrix metalloproteases

7月 8 - 9, 2017 • University of New England • Gordon Research SeminarStatus: Acceptance CancelledRole: Attendee

Educational Background
  • nstructor, Dana-Farber Cancer Institute, Adult Oncology. Harvard Medical School
  • Postdoctoral Research Fellow, Department of Cell Biology, Newborn Medicine, Children Hospital, Harvard Medical School
  • Postdoctoral Research Fellow, MGH Cancer Research Center, Department of Pathology, Molecular Pathology unit, Harvard Medical School
  • Ph.D University of Miami, School of Medicine, Department of Biochemistry, Molecular and Cell Biology.

2 Vacancies

Job Description

Investigate mitochondria targets anti cancer stem cell therapy for SH-Sy5y cell model by using Cell culture, confocal image analysis, western blot, PCR,  biochemical analysis,  transgenic animal model, etc.

Preferred Intern Education Level

graduate or Undergraduate students prefered, senior high student who are interested in applying med school or biology students.

Skill sets or Qualities

cell culture, western blot, PCR, molecular cloning, transgenic animal tech (prefer)