Wen-Pin Hu received his B.S. degree in Mechanical Engineering from National Sun Yat-sen University in Kaohsiung City, Taiwan. He completed his M.S. and Ph.D. degrees at the Institute of Biomedical Engineering at National Cheng Kung University in Tainan City, Taiwan. He was a visiting scholar at the University of Washington in Seattle, USA, from August 2005 to March 2006. His research interests include biosensors, biomolecular simulations, aptasensors, biomechanics, and more. Recently, his research has focused on the refinement of aptamers using computational approaches, the application of aptamers in sensors, and pressure sensing insoles for gait analysis.

The primary research focus of this laboratory is on biosensors and computer-aided aptamer screening. We apply existing technologies such as molecular simulation and artificial intelligence to analyze and predict numerous aptamer sequences, their structures, and their binding affinities with target proteins using computational methods.

After computational analysis, candidate sequences with high binding affinity to target proteins are identified and initially tested using enzyme-linked immunosorbent assay (ELISA). Further validation is conducted through quartz crystal microbalance (QCM), surface plasmon resonance (SPR) biosensors, or field-effect transistor (FET) biosensors for more detailed analysis.

Our laboratory is equipped with the necessary instruments for basic biological experiments, as well as computers capable of performing molecular simulations. Additionally, we have pressure-sensing insoles for gait analysis experiments, which can be utilized for assessing certain aspects of physical performance.