Plant Pathology & Data Analysis Lab
Research Field
Dr. Hao-Xun Chang is an Associate Professor in the Department of Plant Pathology and Microbiology at National Taiwan University (NTU). He earned his bachelor's degree from NTU between 2007 and 2011, followed by a Ph.D. and M.S. from the University of Illinois at Urbana-Champaign under the mentorship of Dr. Glen Hartman from 2012 to 2016. Postdoctoral research positions at the USDA/University of Illinois (Dr. Glen Hartman's team) and Michigan State University (Dr. Martin Chilvers' team) further enriched his expertise in plant pathology. His research interests encompass genome-wide association studies (GWAS), fungal genetics and biology, molecular plant-microbe interactions, genetics and genomics of plants and fungi, microbiome studies, and next-generation sequencing data analyses. Dr. Chang has contributed significantly to the scientific community, serving as a Senior Editor for the journal Plant Disease, BMC Plant Biology, BMC Genomics, and PLOS ONE for years. Dr. Chang also holds the “Microbiome and Plant Health” in the Plant Animal Genome (PAG) conference for years, reflecting his impact on the field.
The Plant Pathology & Data Analysis Lab at NTU, led by Dr. Chang, is dedicated to advancing the understanding of plant diseases through a combination of traditional pathology and modern data analysis techniques. The lab is located in Room 812/816 of the MK Innovation Hall within NTU's College of Bio-Resources & Agriculture. The team comprises researchers and graduate students who collaborate on various projects aimed at deciphering the complexities of plant-pathogen interactions. The lab emphasizes a multidisciplinary approach, integrating molecular biology, bioinformatics, and quantitative genetics to address pressing topics in plant health. Recent recruitment efforts highlight the lab's focus on studying fungal pathogens, microbiomes, and plant resistance mechanisms. The lab fosters a collaborative environment, welcoming international scholars and offering opportunities for postdoctoral fellows, Ph.D. students, and research assistants to engage in cutting-edge research.
At the Plant Pathology & Data Analysis Lab, we are committed to fostering a diverse, inclusive, and equitable environment where individuals of all backgrounds, identities, and experiences feel valued and empowered. Science thrives when diverse perspectives come together, and we actively support the inclusion of underrepresented groups, including LGBTQ+ individuals, racial and ethnic minorities, and cultural diversity.
Dr. Chang's lab focuses on several key areas within plant pathology and data analysis:
- Fungal Pathogen Evolution: Investigating the evolutionary mechanisms of fungal pathogens, using molecular biology, evolutionary transcriptomics, and comparative genomics.
- Soybean Genomics and Disease Resistance: Conducting genome sequencing and assembly of soybean genomes to identify genetic loci associated with disease resistance. This includes comparative genomics and screening for resistance traits to enhance soybean resilience against pathogens.
- Microbiome Studies: Exploring the composition and function of plant-associated microbiomes, with a focus on understanding how microbial communities influence plant health and disease outcomes.
- Bioinformatics and Data Analysis: Applying bioinformatics tools and quantitative genetic analyses to dissect complex datasets, facilitating the identification of key genetic factors involved in plant-pathogen interactions.
These research endeavors aim to develop sustainable strategies for disease management in crops, contributing to global agricultural productivity and food security. The lab's integrative approach combines experimental and computational methodologies to address complex biological questions in plant pathology.
2019-2025 Yushan Young Scholar Fellow
2022, 2023 NTU Outstanding Teaching Awards
2017-2019 Postdoc Michigan State University (Dr. Martin Chilvers' team)
2016-2017 Postdoc USDA / University of Illinois at Urbana-Champaign (Dr. Glen Hartman's team)
2012-2016 Ph.D./M.S. Department of Crop Sciences, University of Illinois at Urbana-Champaign (Dr. Glen Hartman's team)
2007-2011 Bachelor Department of Plant Pathology and Microbiology, National Taiwan University
2 Vacancies
Job Description
What you can learn:
- Fungal genetics and biology, e.g. generation of target-gene knockout mutants, over-expression transformants, and functional validation such as pathogenicity assay and RT-qPCR.
- Plant disease resistance, e.g. QTL mapping, GWAS, BSA, BSA-Seq, and KASP PCR for allele analysis.
- Microbiome, e.g. alpha-, beta-diversity analysis, differential abundance analysis, and co-occurence network.
- Genomics, e.g. genome assembly and annotation, comparative genomics, and evolutionary genomics.
Preferred Intern Education Level
- Undergraduate students (junior/senior) in plant pathology, agronomy, microbiology, plant sciences, or related life science background.
- M.S. students in plant pathology, agronomy, microbiology, or plant sciences background.
- Ph.D. students in plant pathology, agronomy, microbiology, or plant sciences background.
Skill sets or Qualities
- Comfortable with R language for applied statistics and bioinformatics.
- Experience with Linux, Unix, and command line in terminals.
- Experience with plant (e.g. soybean, legume, or Arabidopsis) and microbes (e.g. Agrobacteria and filamentous fungi) cultivation and maintenance.
- Experience with molecular biology (e.g. Primer design, PCR, Gel electrophoresis, cloning).
- Experience with high-throughput sequencing data (e.g. Illumina and PacBio) for quality control, genome assembly and annotation, RNA-Seq analysis, phylogenetic analyses.