National Taipei University of Technology (Taipei Tech)

Electrochemical-Biosensors Lab

PONNUSAMY ARUL
https://che.ntut.edu.tw/p/412-1078-10798.php?Lang=zh-tw

Research Field

Chemistry

Introduction

Dr. Ponnusamy Arul's responsibility is to serve as a Research Assistant Professor at the Department of Chemical Engineering and Biotechnology, Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology (Taipei Tech), Taiwan-106. He also served as a post-doctoral fellow under the direction of Distinguished Prof. Sheng-Tung Huang at the Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, from 2020 to 2022. He obtained a doctoral degree in chemistry (Ph.D) (DST-INSPIRE Fellow by the Government of India) in the Department of Chemistry, The Gandhigram Rural Institute, Dindigul, Tamil Nadu, India, under Prof. Abraham John's mentorship. He also received a Master of Philosophy (M.Phil) from the School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India. He also received a Master's degree (M.Sc) with a gold medal fellow from Periyar University, Salem, Tamil Nadu, India. He holds a Bachelor's degree from Aringnar Anna College, Periyar University, Salem, Tamil Nadu, India. He develops metal-free and metal-containing organic frameworks and hybrid functional materials for diverse functional electrocatalysis. His current research involves developing electrochemical and biosensors and monitoring biological live cell systems in real-time.

Welcome to the “Electrochemical-Biosensors Lab” (https://che.ntut.edu.tw/p/412-1078-10798.php?Lang=zh-tw and https://vpsarul.wixsite.com/mysite), Department of Chemical Engineering and Biotechnology, Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan-106. To date, we have developed an electrochemical sensor that detects a variety of significant environmental and food-based chemicals, biological targets, biomarkers, and other key targets. The catalysts are metal- and metal-free organic frameworks, and zeolitic imidazolate frameworks, and their hybrid composites include metal oxides, carbon composites, graphene/carbon quantum dots, Mxene, MoS2, metal nanoparticles, and so on. Multispectral and microscopic analysis methods are used to verify the catalytic properties of the designed catalysts and confirm. The research aimed to investigate chemical and biological target signals, sensor sensing capacity, characteristic behavior of the sensor assay, rate reaction kinetics, correlation coefficient points, anti-interference ability, stability, reproducibility, etc. Furthermore, detecting electrode fouling behavior, degradation of oxidization or reduction products from the analyzed sensor signal, and reproducibility of sensors. The key objectives of the biosensor are to validate the real-time practical quantitative analysis of direct complex bodily fluid samples (direct human blood, urine, sweat samples) and real living cells (endogenous target release from biological live cells with the help of suitable chemical inducers) and exogenous release of the target from chemical donors to monitor disease progression. Finally, conventional laboratory-based sensor systems have shifted to flexible point-of-care (POC) and commercial sensor devices.   


Research Topics

Aspects of research interests: Metal- and metal-free organic frameworks; Zeolitic organic framework; Nanomaterials with nanoparticles; Metal oxides; Electrochemistry; Spectrophotometry and fluorometry; Materials chemistry; Surface Chemistry; Chemical Sensors; Biosensors; Clinical diagnostics; Live cells and exogenous donors. The following points are a list of research interests.

  • Synthesis, characterization, and surface modification of metallic- and non-metallic organic frameworks based on different kinds of aromatic/aliphatic ligands and metal sites.
  • Development of novel and acceptable strategies for the attachment of different framework structures and their composites. These include metal nanoparticles, metal oxide, graphene, Mxene, MoS2, carbon nanotubes, and carbon/graphene dots for electrochemical and optical sensors and energy applications
  • Controlled growth of microstructures and characterization of different MOFs and ZIFs on Ni foam and other film surfaces (GC, ITO, FTO, and flexible electrode surfaces of LSPE and LSGE).

Five key research areas to be addressed: (1) Clinical analysis: Sensors for metabolites, biomarkers (Tumor, Stroke, Cardiac, Alzheimer's disease, etc.), amino acids, vitamins, and drugs. Biomimetic redox substrates and materials for immobilizing enzymes. (2) Food, water, and environmental safety: Sensors detect toxic compounds to ensure water and environmental safety. (3) Green energy devices: Surface engineering of molecular electrocatalysts and nanostructured materials for biofuel cells and supercapacitor applications. (4) Real-time quantification of endogenous biomarkers: Reactive biomarkers and cell signaling molecules provide valuable health information. (5) Flexible and portable sensors: By combining SPE and LSGE technology with functional materials, selective and sensitive detection platforms for key biomarkers.

As a final note, recent research has focused on biosensors and successful quantification of real-life samples with patient samples to distinguish standard levels and control disease progression. A shift from conventional detection systems to flexible POC devices has resulted in on-site analysis and the design of commercial detection systems being monitored on-site.  


Honor
  • Team member of the High-Value Biomaterials Research and Commercialization Center at the National Taipei University of Technology, Taipei, Taiwan.
  • Review Editor for Carbon-Based Materials, Frontiers in Materials.
  • Key potential journal reviewers in Science Direct (Elsevier), RSC, ACS, Springer Nature, MDPI and so on
  • Role of Research Assistant Professor at the Department of Chemical Engineering and Biotechnology, NTUT, Taipei, Taiwan (from Aug-2022 onwards).
  • Member of the Sakura Science Program (SSP) and Sakura Science Club (SSC) in Japan. 
  • ​SAKURA Science Exchange Fellow at Saga University, Japan by the Japan Science and Technology Agency (July 24 to August 7th, 2018).
  • ​Short-Term Research Fellow at Universiti Putra Malaysia, Malaysia (May 07 to May 19, 2018).
  • ​Best research paper award “Second international conference on electrochemical science and technology (ICONEST-2017, J.N. Tata Auditorium, IISc Bengaluru, Karnataka, India (August 10-12, 2017).
  • Prestigious ​DST-Inspire Fellow awarded by the Government of India (Year of 2015).
  • ​Scored First rank with a Gold medal in Master of Science in Chemistry (2012-2014) at Periyar University, Salem, Tamil Nadu, India.
  • Secured college first rank with a medal in Bachelor of Science in Chemistry at Aringnar Anna College (Arts and Science) (2008-2011) Krishnagiri, affiliated to Periyar University, Salem, Tamil Nadu, India.

Educational Background
  • Doctor of Philosophy (Ph.D.)-Chemistry (2015-2019): The Gandhigram Rural Institute, Dindigul, Tamil Nadu, India.          Thesis Title: Synthesis, Characterization and Electrocatalytic Application of Metallic and Non-Metallic Organic Frameworks.
  • Master of Philosophy (M.Phil)-Chemistry (2014-2015): School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India.
  • Master of Science (M.Sc)-Chemistry (2012-2014): Periyar University, Salem, Tamil Nadu, India.
  • Bachelor of Education (B.Ed)-Physical Science (2011-2012): Institute of Advanced Study in Education, Saidapet, Chennai, Tamil Nadu, India.
  • Bachelor of Science (B.Sc)-Chemistry (2009-2011): Aringnar Anna College, Periyar University, Salem, Tamil Nadu, India.
  • Diploma in Teacher Education (D.T.Ed) (2006-2008): Venkateswara Teacher Training Institute, Pondicherry, India.