National Chung Hsing University

The Lai lab-Physical Chemistry of RNA in Protocell

Yei-Chen Lai
https://ycllab.mystrikingly.com

Research Field

Chemistry

Introduction

Yei-Chen Lai is an assistant professor in the Department of Chemistry at National Chung Hsing University. He received a B.A. and a Ph.D. in Chemistry from National Tsing Hua University, Taiwan, advised by Dr. Yun-Wei Chiang. He received Postdoctoral Research Abroad Fellowship from MOST, Taiwan (107年度科技部補助國外從事博士後研究計畫). He then joined Prof. Irene A. Chen's group at the University of California, Santa Barbara (2018), and then moved to the University of California, Los Angeles (2020).

Our lab investigates the complex world of biological systems, focusing mainly on the structural dynamics and functional connections of RNA molecules. We carefully examine RNA behavior in various chemical environments using spectroscopy methods such as fluorescence and electron spin resonance (ESR). Our research combines experimental research with theoretical insights, allowing us to reveal the dynamic nature of RNA. We aim to enhance the scientific community's understanding of RNA's critical roles in essential biological processes.


Research Topics

How life emerged?

We study how current biology could evolve from the RNA world. We build and create protocells to understand why cellular structure is essential to the current biology.

How RNA works?

The structural dynamic of functional RNA correlates with its activity. Such correlation is often complex and largely depends on environments. We use spin-label ESR spectroscopy to resolve the complex structural dynamics of functional RNAs.

How to pick useful RNAs?

We use in-vitro selection as a strategy to select functional RNAs for bioengineering and fundamental research purposes.


Honor
  • 2018-2019 Postdoctoral research abroad program fellow (funded by MOST, Taiwan) 
  • 2015-2016 Scholarship of Chung Hua rotary educational foundation 
  • 2016 HOPE meeting fellow (8th HOPE Meeting) 
  • 2015 Scholarship of CTCI (China Technical Consultants, Inc.) foundation 
  • 2014 Members of the Phi Tau Phi scholastic honor society of the Republic of China 
  • 2012 and 2013 Chi Mei Corporation Scholarship 
  • 2011 NTHU President’s Scholarship 

Educational Background
  • Ph. D., National Tsing Hua University (2016)
  • B. S., Nation Tsing Hua University (2010)