Lab of Pharmaceutical Analysis
Research Field
Dr. Hsiao-Wei Liao
Title and Position: Associate Professor, Associate Professor National Yang Ming Chiao Tung University
Research Interests: Dr. Hsiao-Wei Liao specializes in the development and application of advanced analytical techniques. His research interests include:
- Liquid Chromatography-Mass Spectrometry (LC-MS)
- Capillary Electrophoresis-Mass Spectrometry (CE-MS)
- Pharmaceutical and Clinical Analysis
- Metabolomics and Lipidomics
- Single-Cell Analysis
- Foodomics
- Multiomics and Sequential Isolation Methods
Development and Application of Analytical Techniques
Welcome to our lab, where we are dedicated to the development and application of cutting-edge analytical techniques. Our primary focus is on creating and refining methods to analyze various target analytes of interest. By utilizing advanced tools and methodologies, we aim to push the boundaries of scientific research and uncover new insights across multiple disciplines.
Our Research Areas Include:
- Pharmaceuticals: Identifying and quantifying pharmaceutical compounds to ensure safety and efficacy.
- Medicine: Applying analytical techniques to enhance clinical research and patient care.
- Food Science: Investigating food safety, quality, and the impact of natural veterinary herbal medicine products.
- Basic Sciences: Delving into the fundamental aspects of biological and chemical processes.
Our Approach:
Through the lens of analytical chemistry, we explore the intricacies of biological systems, striving to reveal the mysteries that lie within. Our state-of-the-art facilities and collaborative environment enable us to conduct high-impact research that contributes to scientific knowledge and practical applications.
Why Join Us?
We invite passionate and inquisitive individuals to join our team. Whether you are a student, researcher, or industry professional, our lab offers a dynamic and supportive setting for advancing your skills and contributing to meaningful discoveries.
Collaborations and Achievements:
Our lab collaborates with leading academic institutions and industry partners worldwide. Our work has been published in top-tier journals, and we have received numerous awards and recognitions for our contributions to the field of analytical chemistry.
Research Topics
Liquid Chromatography-Mass Spectrometry (LC-MS)
- Pharmaceutical Analysis: Developing methods to analyze and quantify pharmaceutical compounds.
- Biological Analysis: Investigating biological samples for various metabolites and biomarkers.
Capillary Electrophoresis-Mass Spectrometry (CE-MS)
- Pharmaceutical Analysis: Advanced techniques for drug analysis and quantification.
- On-line Concentration Techniques: Enhancing sensitivity and detection limits in CE-MS.
Postcolumn Infused-Internal Standard (PCI-IS) Strategy
- Drug Quantification: Accurate measurement of drug concentrations in complex matrices.
- Matrix Effect Correction: Mitigating interference effects in analytical measurements.
- Endogenous Compound Quantification: Quantifying naturally occurring compounds in biological samples.
Pharmaceutical Analysis
- Pharmaceutical Identification: Identifying active ingredients and impurities.
- Pharmaceutical Quantification: Precise measurement of drug components.
Clinical Analysis
- Therapeutic Drug Monitoring (TDM): Monitoring drug levels to ensure therapeutic efficacy and safety.
- Dried Blood Spot Analysis: Convenient and minimally invasive sampling method for various analyses.
- Blood Volume Correction / Hematocrit (Hct) Correction: Ensuring accurate measurement despite variations in blood sample volume.
Metabolomics
- Targeted Metabolite Quantification: Focused analysis of specific metabolites.
- Untargeted Metabolomics: Comprehensive profiling of all metabolites in a sample.
Lipidomics
- Targeted Lipid Quantification: Precise measurement of specific lipids.
- Untargeted Lipidomics: Broad analysis of lipid profiles.
Single-Cell Analysis
- Single-Cell CE-MS Metabolomics: High-resolution metabolite analysis at the single-cell level.
- Tracing Peptides at Single-Cell Level: Detailed peptide mapping within individual cells.
Foodomics
- Unexpected Contaminant Screening: Identifying and quantifying unexpected contaminants in food products.
- Natural Veterinary Herbal Medicine Products: Analyzing the composition and efficacy of herbal medicines for veterinary use.
Metabolomics & Microbiota
- Metabolomics & Exometabolomics: Studying metabolites within organisms and in their surrounding environment.
- Pharmacomicrobiomics: Exploring the interactions between drugs and the microbiome.
Sequential Isolation Method
- Simultaneous Extraction of DNA/RNA/Protein/Metabolites/Lipids: Efficiently isolating multiple biomolecules from a single sample.
- Assisting Multiomics: Supporting comprehensive multiomics studies by providing integrated extraction methods.
Collaborations and Achievements
Our lab collaborates with leading institutions and has published numerous papers in top-tier journals. We welcome passionate researchers and industry partners to join us in our cutting-edge projects.
1. 2023 The Symposium for Pharmaceutical Sciences between Tohoku University and National Yang Ming Chiao Tung University (oral presentation)
2. 2023 Asia－Oceania Mass Spectrometry Conference and the Annual Meeting of the Korean Society for Mass Spectrometry（AOMSC－KSMS 2023）(oral presentation)
3. 2023 Taiwan Society for Mass Spectrometry Annual Conference (oral presentation)
4. 2022 Taiwan Metabolomics Society Annual Conference (oral presentation)
5. 2022 Taiwan Society for Mass Spectrometry Annual Conference (oral presentation)
Educational Background:
- Ph.D. in School of Pharmacy, National Taiwan University (2014)
- B.S. in School of Pharmacy, National Taiwan University (2008)
Professional Experience:
- 2023-Present: Associate Professor, National Yang Ming Chiao Tung University
- 2019-2023: Assistant Professor, National Yang Ming Chiao Tung University
- 2017-2019: Visiting Scholar, University of Illinois at Urbana-Champaign
- 2014-2017: Postdoctoral Fellow, National Taiwan University
1 Vacancy
Job Description
None
Preferred Intern Education Level
None
Skill sets or Qualities
Analytical Chemistry
Organic Chemistry
Biology