National Cheng Kung University

Jhen-Wei Ruan's Laboratory

Jhen-Wei Ruan
https://mt.ncku.edu.tw/p/404-1151-251018.php?Lang=zh-tw

Research Field

Medicine

Introduction

I am currently a tenure-track Assistant Professor of Clinical Microbiology in the Department of Medical Laboratory Science and Biotechnology in the College of Medicine, National Cheng Kung University. In the summer of 2017, I completed my postdoctoral training at the Immunology Research Center, NHRI, and joined the faculty at NCKU. 

At NCKU, I have two primary missions in College of Medicine. The first is to offer the courses of Clinical Microbiology, Clinical Microbiology Lab., and Clinical Microbiology Practice for undergraduate students and Human Microbiome for graduate students. The second is to help NCKU Hospital (NCKUH) establish the workflow of using metagenomic sequencing (mNGS) in pathogen identification and antibiotic-resistance prediction. As a young and junior faculty, I endeavor to balance my teaching, research, and service commitments, which are 45% teaching, 45% research, and 10% service. 

My lab primarily focuses on inflammatory gut diseases and metabolic disorders to the environment-host-microbiome interaction. I am interested in understanding how a host keeps gut microbiota on a leash. Although a microbiota usually changes constantly, the dynamic balance between microbes will be critical for maintaining host healthy conditions. However, how different human mucosal layers regulate the plasticity of microbial communities remains underexplored. We use sequence-based approaches (16S amplicon, metagenomics, genomics, and transcriptomics) in combination with mouse models to understand the role of host regulation (e.g., innate immunity, bile acids) in maintaining microbiome homeostasis.


Research Topics

My lab divides research into three focal areas: (1) investigate the mechanism regulating gut microbiome plasticity, (2) identify dysbiotic signatures of disease-associated microbiota in humans with metagenomic and culturomic approaches, and (3) understand the host-control mechanisms of mucosal hydrogen peroxide level.


Honor

2022 NCKU Best Mentoring Teacher Award


Educational Background

2005-2012, Ph.D. degree in Medical Sciences, Tzu-Chi University, Hualien, Taiwan (Mentor: Dr. Ji-Hsiung Chen)

Research: Characterizing the role of pttg1 gene in cellular senescence, Inflammation, and breast cancer metastasis.


1 Vacancy

Job Description

We are inviting applications for a Research Intern to join our team in exploring host-microbe interactions with a focus on using Caenorhabditis elegans as a model organism. This role is ideal for candidates who are interested in microbial ecology, genetics, and the mechanisms of microbial influence on host biology. The intern will be involved in conducting experimental research under the guidance of our scientific team, contributing to our understanding of microbial impacts on host health and development.

Preferred Intern Education Level

Undergraduate student

Skill sets or Qualities

  • Eager to learn and gain hands-on experience.
  • Has specific perspectives and enthusiasm to the lab.